It's Fun Time with Yeast DNA! New paper!
Differential enrichment of yeast DNA in SARS-CoV-2 and related genomes supports synthetic origin hypothesis
46 Pages, Posted: Andreas Martin Lisewski
Jacobs University, June 5, 2021
papers.ssrn.com/sol3/papers.cf…
I will be reading this now
Crikey! SARS 1 SARS COV 2 and RaTG13!
Diagram 1
Diagram 2
Proposed Passage Model - Joder
RaTG13 off the hook. Phew, had me worried there!
"Thus SARS-CoV-2 and SARS-CoV-1 both did, but
RaTG13 did not fit into our synthetic passage model"
Specific scheme for the synthetic biogenesis of SARS-CoV-2 and SARS-CoV-1 in transformed yeast cells
How it works
Taken together, our results reveal a highly differential homology signal on SARS-CoV-2 and SARS-CoV-1 genomes which points to their history of targeted integration, recombination, and directed viral replication through passage in an artificial S. cerevisiae host.
RaTG13 back on the hook?
This genomic signal suggests similar synthetic origins of SARS-1 & SARS-CoV-2.. A special case is RaTG13, which produces a simpler pattern of common genetic history with yeast than the 2 mutually more similar homology signals found in SARS-1 & SARS CoV-2
Hmmm...
"This divergence suggests that if RaTG13 is assumed to be a product of natural evolution then both the sequences of SARS-CoV-1 and SARS-CoV-2 cannot be. Alternatively, the origin of RaTG13 could be artificial—along with SARS-CoV-2 and SARS-CoV-1, as our results suggest"
Last points
1. Identification of the input progenitor
2. Reversal mutations - early outbreak
"Natural Origin" has just been buried in Bremen Yeast!
A big Thank you to:
Andreas Martin Lisewski
Department of Life Sciences and Chemistry
Jacobs University Bremen
Email: a.lisewski@jacobs-university.de
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