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Billy Bostickson 🏴👁&👁 🆓 Profile picture
@BillyBostickson
Jun 9, 2021 • 13 tweets • 5 min read • Read on X
Scrolly
It's Fun Time with Yeast DNA! New paper!
Differential enrichment of yeast DNA in SARS-CoV-2 and related genomes supports synthetic origin hypothesis
46 Pages, Posted: Andreas Martin Lisewski
Jacobs University, June 5, 2021
papers.ssrn.com/sol3/papers.cf…
I will be reading this now
Crikey! SARS 1 SARS COV 2 and RaTG13!
Diagram 1
Diagram 2
Proposed Passage Model - Joder
RaTG13 off the hook. Phew, had me worried there!

"Thus SARS-CoV-2 and SARS-CoV-1 both did, but
RaTG13 did not fit into our synthetic passage model"
Specific scheme for the synthetic biogenesis of SARS-CoV-2 and SARS-CoV-1 in transformed yeast cells

How it works
Taken together, our results reveal a highly differential homology signal on SARS-CoV-2 and SARS-CoV-1 genomes which points to their history of targeted integration, recombination, and directed viral replication through passage in an artificial S. cerevisiae host.
RaTG13 back on the hook?
This genomic signal suggests similar synthetic origins of SARS-1 & SARS-CoV-2.. A special case is RaTG13, which produces a simpler pattern of common genetic history with yeast than the 2 mutually more similar homology signals found in SARS-1 & SARS CoV-2
Hmmm...
"This divergence suggests that if RaTG13 is assumed to be a product of natural evolution then both the sequences of SARS-CoV-1 and SARS-CoV-2 cannot be. Alternatively, the origin of RaTG13 could be artificial—along with SARS-CoV-2 and SARS-CoV-1, as our results suggest"
Last points
1. Identification of the input progenitor
2. Reversal mutations - early outbreak
"Natural Origin" has just been buried in Bremen Yeast!
A big Thank you to:
Andreas Martin Lisewski
Department of Life Sciences and Chemistry
Jacobs University Bremen
Email: a.lisewski@jacobs-university.de
unroll Bremen Yeast @threadreaderapp

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More from @BillyBostickson

Billy Bostickson 🏴👁&👁 🆓 Profile picture
Nov 8
@Daoyu15 @jhas5 @Fynnderella1 Not sure what your point is ragrding hACE2 mice infection.

Have you read all the other hACE2 mouse model papers that show SC2 infection.

I have!

Here are 15 of them, please read them:

1. Animal models for SC2 and SC1 pathogenesis & transmission

pmc.ncbi.nlm.nih.gov/articles/PMC87…
@Daoyu15 @jhas5 @Fynnderella1 2. Mouse Models for SC2 Infection

pmc.ncbi.nlm.nih.gov/articles/PMC85…

3. Highly susceptible hACE2-transgenic mouse model for SC-2 research

frontiersin.org/journals/micro…

4. Inducible hACE2 transgenic mouse model recapitulates SC-2 infection & pathogenesis in vivo

pnas.org/doi/abs/10.107…
@Daoyu15 @jhas5 @Fynnderella1 5. Mouse Model of SC-2 Infection & Pathogenesis

sciencedirect.com/science/articl…

6. Mouse models of lung-specific SC-2 infection

frontiersin.org/journals/immun…

7. Comparison of transgenic & adenovirus hACE2 mouse models for SARS-CoV-2 infection

tandfonline.com/doi/full/10.10…
Read 8 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Nov 7
@Ticklicker56 @Biorealism Yes, we thoroughy researched this issue some time ago.

Difficult to prove anything, but certainly raises suspicions.
@Ticklicker56 @Biorealism Interestingly, the E protein and nsp7 of ZC45 are 100% identical to those of SARS-COV-2.

Even Holmes (Wu et al., 2020) listed ZC45 as closest in Feb 2020 until the RaTG13 full genome was published in March

nature.com/articles/s4158…
@Ticklicker56 @Biorealism Phylogenetic trees and analysis from the early days

nature.com/articles/s4158…

What's unusual is that Wu & Holmes (2020) did NOT inlcude the RdRp of SC2 in the analysis

Holmes definitely knew of the RdRp of RaTG13 (4991) and RaTG13's sequence since 2018

x.com/tlitb/status/1… Image
Image
Image
Image
Read 6 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Oct 15
🧵The Censorship of an Innocent Monkey!

by the following Western "science" websites:

@biorxivpreprint

@medrxivpreprint

and Chinese news websites:

@globaltimesnews

@PDChina

Let's see what disturbs them so much that they have to censor certain comments?
1. @biorxivpreprint August 2024 Image
@biorxivpreprint 2. @biorxivpreprint 3 years ago Image
Read 38 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Oct 6
1. Spiked: The Hunt For The Origin of Covid-19

Good news @BlueAntMedia is going to publish it

Many #DRASTIC interviews including myself 🐵

"SPIKED tells the inside story of one of humanity’s biggest & most pressing mysteries: the debate over the origins of COVID-19"

Clip 👇
2. The Making of the Documentary (20 minutes)

"Unfolding like true crime, this detective story takes us deep into clashing conspiracy theories & partisanship while exposing the dangers posed by experiments regularly taking place in the world’s biolabs"

worldscreenevents.com/premieres/spik…
3. Our film is a true crime detective thriller

"It’s about the future of biotech and the next pandemic. We wanted to make a contentious story really exciting, with twists and turns, that covers the science but with a strong dramatic structure"

broadcastnow.co.uk/broadcast-netw…
Read 8 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Sep 14
1. "Baseless" = How the Media Gaslights You

The 4Ds: Dismiss, Distract, Distort, Dismay

7 posts with video evidence of cat eating by Haitian immigrants in the comments

and this is why they hate @X

Because their lies & propaganda are exposed

Their Masters have lost control!
2. A Haitian Woman in the US speaks out

3. Haitian-American, whose family members ate cats, SPEAKS OUT against illegal migration.

Read 12 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Sep 9
1. "For me with this data a lab origin is now more than likely" says @dr_louwen

Referring to ON876210 ( i think ;)



From authors of this paper (Submitted March 2020)

An Infectious cDNA Clone of SARS-CoV-2



h/t @Rebecca21951651 ncbi.nlm.nih.gov/nuccore/ON8762…
ncbi.nlm.nih.gov/pmc/articles/P…
2. From 2020 Paper

“icSars_CoV_2 retained the engineered molecular markers & did not acquire other mutations”.

@dr_louwen considers that:

1. This increases the validity of the genetic finding

2. This isolate is highly similar to the wild type isolate 2019-nCoV/USA_WA1/2020
@dr_louwen 3. Point 2 above refers to "ON876210"

(My mistake in Tweet 1)

Submitted (29-JUN-2022) in the USA

ncbi.nlm.nih.gov/nuccore/ON8762…
Read 4 tweets

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