.@BradRovin speaking on the evolution of #lupus therapy over the years in @isn_india Masterclass
The main change which has happened is to decrease steroids.
Probably 1 gm of MPS is enough to begin treatment in #lupus
Discussing the data on minimizing steroids @BradRovin shows data by @kidneydoc101 which formed the basis of RITUXILUP
Are we going towards NO steroids for #lupus ?
Hope at the end of the tunnel. Positive trials upcoming new Rx for #lupus
Is obinutuzumab better than rituximab
How is #Voclosporin different from CSA?
Less need for TDM monitoring
high potency
low glucose / lipid side effects
.@BradRovin discusses pooled AURA - LV and AURORA trial
Very hopeful results
Check out #visualabstract and summary in @LastNeph Also, soon to be discussed in @NephJC
Subgroup analysis of AURORA
Is it same for all races and all LN Class? pts on MMF had more significant different (can be related to disease severity)
#voclosporin might not be the first choice for pts with severely reduced GFR
Moving to Belimumab - It reduces flares (even in kids) and slows progression to ESKD when added to background therapy
.@BradRovin is very hopeful about Obintuzumab and 2 doses of MPS with MMF might make #lupus pts steroids free!! @kidneydoc101
He is also talking about subtyping pts who have B cell dominant disease to target for these therapies
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