.@BradRovin speaking on the evolution of #lupus therapy over the years in @isn_india Masterclass
The main change which has happened is to decrease steroids.
The main change which has happened is to decrease steroids.
Probably 1 gm of MPS is enough to begin treatment in #lupus
Discussing the data on minimizing steroids @BradRovin shows data by @kidneydoc101 which formed the basis of RITUXILUP
Are we going towards NO steroids for #lupus ?
Are we going towards NO steroids for #lupus ?
Hope at the end of the tunnel. Positive trials upcoming new Rx for #lupus
Is obinutuzumab better than rituximab
Is obinutuzumab better than rituximab
How is #Voclosporin different from CSA?
Less need for TDM monitoring
high potency
low glucose / lipid side effects
Less need for TDM monitoring
high potency
low glucose / lipid side effects
.@BradRovin discusses pooled AURA - LV and AURORA trial
Very hopeful results
Check out #visualabstract and summary in @LastNeph Also, soon to be discussed in @NephJC
Very hopeful results
Check out #visualabstract and summary in @LastNeph Also, soon to be discussed in @NephJC
Subgroup analysis of AURORA
Is it same for all races and all LN Class? pts on MMF had more significant different (can be related to disease severity)
Is it same for all races and all LN Class? pts on MMF had more significant different (can be related to disease severity)
#voclosporin might not be the first choice for pts with severely reduced GFR
Moving to Belimumab - It reduces flares (even in kids) and slows progression to ESKD when added to background therapy
.@BradRovin is very hopeful about Obintuzumab and 2 doses of MPS with MMF might make #lupus pts steroids free!! @kidneydoc101
He is also talking about subtyping pts who have B cell dominant disease to target for these therapies
He is also talking about subtyping pts who have B cell dominant disease to target for these therapies
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