🌸Kidney involvement in primary Sjögren Syndrome
🔥<10% cases (Underdiagnosed/ Neglected⁉️)
🔥Most frequent: TIN
🔥Prognosis👍
🔥Good response to steroid
🔥Cryoglobulinaemia in SS👉 Beware of Lymphoma/MPGN‼️
⚠️Always screen kidneys in SS
#NephroNotes #Nephpearls #FOAMed #MedEd
🌸Kidney involvement in primary Sjögren Syndrome
🔥Trigger: Environment/Genetics/Viruses
🔥Immune complex in glomeruli
🔥Autoab to specific renal transporters in DCT (Reason behind dyselectrolytemia‼️)
10.1038/nrneph.2015.174
#NephroNotes #FOAMed #MedEd #Nephpearls #NephTwitter
🌸Kidney involvement in primary Sjögren Syndrome
🔥Clinical presentation
♦️dRTA👉Nephrocalcinosis
♦️DI
♦️Fanconi Syndrome
♦️Bartter/Gitelman
♦️TIN
♦️MPGN
#NephroNotes #Nephpearls #FOAMed #MedEd #MedTwitter
🌸Kidney involvement in primary Sjögren Syndrome
🔥Differentials
⚠️Exclude other inflammatory disorders
SLE/ Chronic HCV/ IgG4 related disease
doi:10.1038/nrneph.2015.174
#NephroNotes #Nephpearls #FOAMed #MedEd #MedTwitter
🌸Kidney involvement in primary Sjögren Syndrome
🔥Frequent infiltration of interstitium with B cells & plasma cells
👉Basis for B-cell targeted therapy
doi:10.1038/nrneph.2015.174
#NephroNotes #Nephpearls #FOAMed #MedEd #MedTwitter
🌸Kidney involvement in primary Sjögren Syndrome
🔥Management
👉Renal outcome better in MPGN than TIN‼️
⚠️key-Early diagnosis & prompt t/t
👉Rituximab
👉TIN: Steroid(≥0.5mg/kg/day)
👉MPGN (cryo): CS+Ritux+TPE
doi:10.1038/nrneph.2015.174
#NephroNotes #Nephpearls #FOAMed #MedEd
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