Jamie Hynes Profile picture
UK GP, FRCGP, Illustrator. Daddy to my boys! Created ‘The National Health’ #GP150w #GPKipling #CIAN #GPsAWonderfulLife #IAMUK Winner. RCGP Faculty Champion & 🪑

Aug 9, 2021, 8 tweets

Vague and Non-Specific Cancer Symptoms: A short Tweetorial.
A bit of context courtesy of #GP150w for the #blackandwhitechallenge faced in Primary Care:
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Vague and Non-Specific Cancer Symptoms
Continuing the shades of grey, we differentiate the specific cancer signatures from those non-specific symptoms, noting the lowering of the threshold for Positive Predictive Value to the current 3% level.
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Vague and Non-specific Cancer Symptoms
So, what does the evidence for new pathways say?
Quite alot of support for 'gut instinct' or Clinical Suspicion- one of the two commonest reasons for referral to Multi-Diagnostic Centres, and statistically significance to support it.
3/7

Vague and Non-specific Cancer Symptoms
A 2021 @BJGPjournal review by the Lead Author has suggested that given the degree of less common cancers diagnosed via MDCs that this pathway exceeds that 3% PPV threshold- opportunity for hope!
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Vague and Non-specific Cancer Symptoms
A useful moment to stop and highlight the data from this @BJGPjournal Systematic Review from Friedemann Smith on how valuable listening to that inner voice is!
bjgp.org/content/70/698…
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Vague and Non-specific Cancer Symptoms
Considering Unexpected Weight Loss:
Helpful evidence from @BrianDNicholson that we don't need to investigate all cases through these pathways, but associations with other features/symptoms should give you the nudge. #PracticeChanging
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Vague and Non-Specific Cancer Symptoms
We're all set to launch our local pathway, but how much will the pandemic affect the 1st presentation of the patient?
Will we see more presenting at late stages and less at the vague or non-specific?
@CRUKHCPs @dottietipsy @_JamesGwilt
7/7

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