The Good, Bad & the Ugly with @THAILANDMEDICA1
1. thailandmedical.news/news/breaking-…
Paper: COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes
insight.jci.org/articles/view/…
2. Does your Brain hurt?
thailandmedical.news/news/saudi-ara…
Paper: Brain MRI in SARS-CoV-2 pneumonia patients with newly developed neurological manifestations suggestive of brain involvement
nature.com/articles/s4159…
3. Yes, my brain hurts, doctor!
thailandmedical.news/news/breaking-…
Paper:
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
nature.com/articles/s4159…
4. Cognitive Decline and Brain Fog
thailandmedical.news/news/icahn-stu…
Paper: Assessment of Cognitive Function in Patients After COVID-19 Infection
jamanetwork.com/journals/jaman…
4. You Microclot! You Inflammatory Molecule!
thailandmedical.news/news/breaking-…
Paper: Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin
cardiab.biomedcentral.com/articles/10.11…
5. Deviled Kidneys?
thailandmedical.news/news/more-grea…
Paper: Kidney Outcomes in Long COVID
jasn.asnjournals.org/content/early/…
jasn.asnjournals.org/content/jnephr…
6. We are all effed?
thailandmedical.news/news/breaking-…
Paper: Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection
A Systematic Review
jamanetwork.com/journals/jaman…
n this systematic review of 57 studies comprising more than 250 000 survivors of COVID-19,
7. How dare you alter my Genes without permission!
thailandmedical.news/news/breaking-…
Paper: Acute COVID-19 gene-expression profiles show multiple etiologies of long-term sequelae
medrxiv.org/content/10.110…
8. New Variants and Mutations (1)
You can run but you can't hide..
thailandmedical.news/news/breaking-…
Paper: The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency
nature.com/articles/s4142…
9. New Variants and Mutations (2)
SARS-COV-2 gets a Break out of Jail Free Card
Hotspot Mutations and Immune Evasion
thailandmedical.news/news/swiss-stu…
Paper: Mutational hotspot in the SARS-CoV-2 Spike protein N-terminal domain conferring immune escape potential
biorxiv.org/content/10.110…
10. New Variants and Mutations (3)
Baton Rouge Mutants
thailandmedical.news/news/louisiana…
News: What do we know about the new Louisiana COVID-19 variant?
deseret.com/coronavirus/20…
11. New Variants and Mutations (4)
Don't go to Cape Cod
thailandmedical.news/news/harvard-a…
Paper: Evidence of transmission from fully vaccinated individuals in a large outbreak of the SARS-CoV-2 Delta variant in Provincetown, Massachusetts
medrxiv.org/content/10.110…
12. Oi, Pfizer, did you just steal my N Antibodies?
thailandmedical.news/news/uk-health…
with useful list of 91 studies on natural immunity
Document (UK):
assets.publishing.service.gov.uk/government/upl…
13. Single agent monoclonal antibodies? Hilarious?
@THAILANDMEDICA1 puts the boot in again(Image 1)
thailandmedical.news/news/hilarious…
Paper: Acquisition & onward transmission of a SARS-CoV-2 E484K variant among household contacts of a bamlanivimab-treated patient
medrxiv.org/content/10.110…
14. One for @Daoyu15 Too complex for me.
Monoclonal Antibody Related
thailandmedical.news/news/breaking-…
Paper: Opsonization by non-neutralizing antibodies can confer protection to SARS-CoV-2 despite Spike-dependent modulation of phagocytosis
biorxiv.org/content/10.110…
15. Role of Lipids
thailandmedical.news/news/universit…
Paper: The roles of lipids in SARS-CoV-2 viral replication and the host immune response
jlr.org/article/S0022-…
16. "Palmitoylation" 🤲🤦🤦♂️🤦♀️
thailandmedical.news/news/universit…
Paper: Inhibition of SARS-CoV-2 spike protein palmitoylation reduces virus infectivity
biorxiv.org/content/10.110…
"Palmitoylation of the 1st 5 cysteine residues of the spike c-terminal cysteine-rich domain are indispensable"
17. Finished with Bad & Ugly, now Good news
1. Manuka Honey
thailandmedical.news/news/qatar-uni…
2. Basil (Fenchol)
thailandmedical.news/news/fenchol-a…
3. Glucose Regulating Drugs
thailandmedical.news/news/penn-stat…
4. Zofran (Antiemetic)
thailandmedical.news/news/new-ameri…
5. Atovaquone (antimicrobial)
thailandmedical.news/news/danish,-c…
18. I hope this thread was not too depressing?
If it was, the solution is at hand, mushroom soup :)
thailandmedical.news/news/penn-stat…
Mushroom intake and depression
"Mushroom consumers had a lower odd of depression"
sciencedirect.com/science/articl…
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