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Billy Bostickson 🏴👁&👁 🆓 Profile picture
@BillyBostickson
Oct 27, 2021 • 20 tweets • 18 min read • Read on X
Scrolly
The Good, Bad & the Ugly with @THAILANDMEDICA1
1. thailandmedical.news/news/breaking-…

Paper: COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes

insight.jci.org/articles/view/…
2. Does your Brain hurt?

thailandmedical.news/news/saudi-ara…

Paper: Brain MRI in SARS-CoV-2 pneumonia patients with newly developed neurological manifestations suggestive of brain involvement

nature.com/articles/s4159…
3. Yes, my brain hurts, doctor!

thailandmedical.news/news/breaking-…

Paper:

The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

nature.com/articles/s4159…
4. Cognitive Decline and Brain Fog

thailandmedical.news/news/icahn-stu…

Paper: Assessment of Cognitive Function in Patients After COVID-19 Infection

jamanetwork.com/journals/jaman…
4. You Microclot! You Inflammatory Molecule!

thailandmedical.news/news/breaking-…

Paper: Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin

cardiab.biomedcentral.com/articles/10.11…
5. Deviled Kidneys?

thailandmedical.news/news/more-grea…

Paper: Kidney Outcomes in Long COVID

jasn.asnjournals.org/content/early/…

jasn.asnjournals.org/content/jnephr…
6. We are all effed?

thailandmedical.news/news/breaking-…

Paper: Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection
A Systematic Review

jamanetwork.com/journals/jaman…

n this systematic review of 57 studies comprising more than 250 000 survivors of COVID-19,
7. How dare you alter my Genes without permission!

thailandmedical.news/news/breaking-…

Paper: Acute COVID-19 gene-expression profiles show multiple etiologies of long-term sequelae

medrxiv.org/content/10.110…
8. New Variants and Mutations (1)

You can run but you can't hide..

thailandmedical.news/news/breaking-…

Paper: The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency

nature.com/articles/s4142…
9. New Variants and Mutations (2)

SARS-COV-2 gets a Break out of Jail Free Card

Hotspot Mutations and Immune Evasion

thailandmedical.news/news/swiss-stu…

Paper: Mutational hotspot in the SARS-CoV-2 Spike protein N-terminal domain conferring immune escape potential

biorxiv.org/content/10.110…
10. New Variants and Mutations (3)

Baton Rouge Mutants

thailandmedical.news/news/louisiana…

News: What do we know about the new Louisiana COVID-19 variant?

deseret.com/coronavirus/20…
11. New Variants and Mutations (4)

Don't go to Cape Cod

thailandmedical.news/news/harvard-a…

Paper: Evidence of transmission from fully vaccinated individuals in a large outbreak of the SARS-CoV-2 Delta variant in Provincetown, Massachusetts

medrxiv.org/content/10.110…
12. Oi, Pfizer, did you just steal my N Antibodies?

thailandmedical.news/news/uk-health…

with useful list of 91 studies on natural immunity

Document (UK):

assets.publishing.service.gov.uk/government/upl…
13. Single agent monoclonal antibodies? Hilarious?

@THAILANDMEDICA1 puts the boot in again(Image 1)
thailandmedical.news/news/hilarious…
Paper: Acquisition & onward transmission of a SARS-CoV-2 E484K variant among household contacts of a bamlanivimab-treated patient
medrxiv.org/content/10.110…
14. One for @Daoyu15 Too complex for me.

Monoclonal Antibody Related

thailandmedical.news/news/breaking-…

Paper: Opsonization by non-neutralizing antibodies can confer protection to SARS-CoV-2 despite Spike-dependent modulation of phagocytosis

biorxiv.org/content/10.110…
15. Role of Lipids

thailandmedical.news/news/universit…

Paper: The roles of lipids in SARS-CoV-2 viral replication and the host immune response

jlr.org/article/S0022-…
16. "Palmitoylation" 🤲🤦🤦‍♂️🤦‍♀️

thailandmedical.news/news/universit…

Paper: Inhibition of SARS-CoV-2 spike protein palmitoylation reduces virus infectivity

biorxiv.org/content/10.110…

"Palmitoylation of the 1st 5 cysteine residues of the spike c-terminal cysteine-rich domain are indispensable"
17. Finished with Bad & Ugly, now Good news
1. Manuka Honey
thailandmedical.news/news/qatar-uni…
2. Basil (Fenchol)
thailandmedical.news/news/fenchol-a…
3. Glucose Regulating Drugs
thailandmedical.news/news/penn-stat…
4. Zofran (Antiemetic)
thailandmedical.news/news/new-ameri…
5. Atovaquone (antimicrobial)
thailandmedical.news/news/danish,-c…
18. I hope this thread was not too depressing?

If it was, the solution is at hand, mushroom soup :)

thailandmedical.news/news/penn-stat…

Mushroom intake and depression

"Mushroom consumers had a lower odd of depression"

sciencedirect.com/science/articl…
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More from @BillyBostickson

Billy Bostickson 🏴👁&👁 🆓 Profile picture
11h
22. Biased Sampling distorts Geography!

They use a dataset skewed toward Yunnan & Laos (p. 16), leading to phylogeographic models that place SARS-CoV ancestors far from Wuhan & Guangdong (p. 12).

This sampling bias undermines the reliability of their geographic inferences.
23. Neglecting Alternative Hypotheses

No SARS-CoV-like viruses near emergence sites?

They completely overlook non-bat reservoirs, like civets or pangolins, which could explain local circulation (p. 15).

This omission weakens their claim of distant ancestor origins (p. 12).
24. Inconsistent Molecular Clock Rates

The paper misuses variable NRR-specific clock rates, which give inconsistent SARS-CoV ancestor dates (e.g., 1944–2014 for SARS-CoV-2, p. 9).

Without any validation of bat-specific rates, this approach has no rational grounding (p. 14).
Read 8 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
14h
5. Why did they resort to using the POW model?

To show that :

"our inferences of the time of the ancestors of human SARS-CoVs and their closest bat sarbecoviruses are UNBIASED"
6. Captain Obvious Strikes Again (1)

"we show that the ancestors of SARS-CoV-1 & SARS-CoV-2 likely circulated in horseshoe bat populations 100s to 1000s km away from the sites of the emergence of these viruses in humans & as recently as one to six years prior to this emergence"
7. Captain Obvious Strikes Again (2)

"Our findings indicate that there would not have been sufficient time for the direct bat virus ancestor to reach the locations of emergence of the human SARS-CoVs via normal dispersal through bat populations alone"
Read 12 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
14h
1. Last sick joke of the Zoonati?

Fragments of human SARS-CoVs share recent common ancestors with bat viruses

SARS-CoV-like viruses have circulated in Asia for millennia

Ancestors of human SARS-CoVs likely circulated in China & Laos

Ancestors traveled unexpectedly fast
2. No Pangolins allowed!

There is insufficient temporal signal when calibrating a molecular clock using tip dating with sarbecoviruses sampled from bats & pangolins, likely as a consequence of limited sampling across space & time.

Therefore, we used SARS-CoV-1 genomes!
3. Definitely no pangolins!

As sampling locations of SARS-CoV-1, 2 & pangolin sarbecoviruses likely do not represent where their direct bat virus ancestors circulated, we EXCLUDED their locations from phylogeographic analyses to avoid the IMPACT of dispersal of non-bat hosts!
Read 24 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
May 4
1⃣ Virological 🦠 Whistleblower 😮‍💨?

"I worked with researchers in this space - virology + combatting future pandemics - in the decade before the pandemic".
2⃣ One Fact

"The one fact that the last 5 years never readily disclosed is that the core ideology of this community of researchers was fundamentally divided"
3⃣ Lab based creation of super-viruses

"About half of the researchers, including many leading virologists whose names appeared in the news, believed and argued passionately for the lab-based creation of super-viruses and super-bacteria"
Read 12 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Apr 23
1. The Second Lab Leak

Turning and turning in the petri dish,
The scientists cannot hear the warnings;
Genes recombine; the barriers cannot hold,
Evil virology is loosed upon the world,
The blood-dimmed tide is loosed, and everywhere
The ceremony of innocence is drowned;
2. The Second Lab Leak

The best lack critical thinking, while the professors
Are full of furious bias.
Surely some revelation is at hand;
Surely the cover up is now banned?
Lab Leak! Hardly are those words out
When a vast image out of Human Folly
Troubles my sight:
3. Somewhere in Wuhan

somewhere in the cell lines of a Chinese laboratory
A shape with pangolin body and the head of a bat,
A gaze blank and pitiless as the sun,
Is moving its long tongue, while all about it
Reel shadows of the indignant molested bats.
Read 6 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Apr 22
🧵As promised, here is my counter critique & rebuttal of some points made by @gadboit about the Pangolin Papers Hypothesis.

His theory seems to be that SARS-COV-2 emerged like Aphrodite, from BANAL BAT viruses, possibly with some FCS tweaking & no Pangolins coronaviruses needed.
🧵1. Introduction

@gadboit claims BANAL-52’s 96.8% similarity and natural recombination outweigh my lab + PangolinCoV hypothesis for SARS-CoV-2’s origin.

However, my evidence shows PangolinCoV signatures, WIV lab work & recombination are stronger.

researchgate.net/publication/39…
@gadboit 🧵2. @gadboit claims BANAL-52’s 96.8% similarity & ACE2 binding make it closer to SARS-CoV-2 than PCoVs (~91%) & that PCoV features could come from bat CoVs.

But GD PCoV’s RBD (97% identity) needs no mutations for hACE2, unlike BANALs.

See Wrobel et al:

nature.com/articles/s4159…
Read 28 tweets

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