The many faces of plasma cell neoplasm, diagnostic challenges of the great imitator in #hemepath ➡️bit.ly/3B3jMC1 with @ljmedeirosMD & @ShiminHuMDPhD #mmsm #lymsm #pathtwitter #leusm
1) The small cell variant (mimicking B-cell lymphoma, particularly mantle cell lymphoma➡️CyclinD1 positive) #hemepath #pathtwitter
2) Cleaved cell variant (mimicking follicular lymphoma) #hemepath #pathtwitter
3) Monocytoid variant (mimicking acute leukemia with monocytic differentiation) #hemepath #pathtwitter
4) Erythroid variant (mimicking pure erythroid leukemia) #hemepath #pathtwitter
5) Megakaryocytoid variant #hemepath #pathtwitter
6) Blastoid variant (mimicking AML) #hemepath #pathtwitter
7) Crystal storing histiocytoisis-like variant #hemepath #pathtwitter
8) Signet ring cell-like variant #hemepath #pathtwitter
9) Oncocytic variant #hemepath #pathtwitter
10) Lobular carcinoma-like variant #hemepath #pathtwitter
11) Pseudoalveolar variant #hemepath #pathtwitter
12) Aberrant cytokeratin expression
And many other unusual morphologic and immunophenotypic presentations here ➡️bit.ly/3B3jMC1
Take home message: If things are not adding up (clinical vs pathology findings), throwing in a CD138 stain will sometimes solve the puzzle
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