The 4th shot is already underway in the UK. Meanwhile, millions of Americans of advanced age are well past 6 months from getting their 3rd shot, with substantial waning of protection, with no plan yet. /1
Reduction in neutralizing antibodies after mRNA vaccines at 5 months /2
nejm.org/doi/full/10.10…
Waning in vaccine effectiveness vs Omicron symptomatic infections and hospitalizations after 3rd dose, all ages @UKHSA /3
assets.publishing.service.gov.uk/government/upl…
In older adults, waning of neutralizing antibodies faster after Omicron than Delta
"In the absence of omicron variant-specific vaccines, booster immunizations are crucial to restore
vaccine effectiveness against severe outcomes." /4
thelancet.com/journals/lanin…
"The [neutralizing antibody] response against Omicron declined 6.3-fold over the same 6-month time frame after the boost." @NatureMedicine /5
nature.com/articles/s4159…
CDC report on waning of 3rd dose vaccine effectiveness vs emergency department and urgent care encounters, age 18+, from 87% < 2 months to 31% > 5 months /6
cdc.gov/mmwr/volumes/7…
Israel started giving a 4th dose to people age 60+ in December and reported short-term benefit of 4-fold protection vs Omicron severe illness /7 medrxiv.org/content/10.110…
More data on durability of protection will be available soon
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