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Eric Topol Profile picture
@EricTopol
Mar 21, 2022 • 7 tweets • 5 min read • Read on X
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The 4th shot is already underway in the UK. Meanwhile, millions of Americans of advanced age are well past 6 months from getting their 3rd shot, with substantial waning of protection, with no plan yet. /1
Reduction in neutralizing antibodies after mRNA vaccines at 5 months /2
nejm.org/doi/full/10.10…
Waning in vaccine effectiveness vs Omicron symptomatic infections and hospitalizations after 3rd dose, all ages @UKHSA /3
assets.publishing.service.gov.uk/government/upl…
In older adults, waning of neutralizing antibodies faster after Omicron than Delta
"In the absence of omicron variant-specific vaccines, booster immunizations are crucial to restore
vaccine effectiveness against severe outcomes." /4
thelancet.com/journals/lanin…
"The [neutralizing antibody] response against Omicron declined 6.3-fold over the same 6-month time frame after the boost." @NatureMedicine /5
nature.com/articles/s4159…
CDC report on waning of 3rd dose vaccine effectiveness vs emergency department and urgent care encounters, age 18+, from 87% < 2 months to 31% > 5 months /6
cdc.gov/mmwr/volumes/7…
Israel started giving a 4th dose to people age 60+ in December and reported short-term benefit of 4-fold protection vs Omicron severe illness /7 medrxiv.org/content/10.110…
More data on durability of protection will be available soon

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More from @EricTopol

Eric Topol Profile picture
Jan 20
Physical activity and the reduction of all-cause mortality, from 2 very large prospective cohorts
1. The relationship is non-linear, suggesting a threshold effect for many types of exercise as seen below Image
2. Engaging in > 1 type of physical activity was generally correlated with better outcomes compared with 1 type (T1,2,3) Image
The @BMJMedicine was supposed to post this paper 2 hours ago but has failed to do. It is being covered by other means medicalxpress.com/news/2026-01-p…
Someday the link will be active!
dx.doi.org/10.1136/bmjmed… Image
Read 5 tweets
Eric Topol Profile picture
Jan 1
People age 70+ should not be taking aspirin at any dose for prevention. Results of randomized trials show higher risk of all-cause mortality, major bleeding events and deaths from cancer. p 153, SUPER AGERS bookImage
President Trump takes 325 mg aspirin/day. The randomized trials tested 75-81 mg/day. His doctors recommended low-dose aspirin for heart event prevention. That recommendation is ill-founded based upon best evidence in older individuals.
nejm.org/doi/full/10.10…
academic.oup.com/eurheartj/arti…Image
Aspirin dosing information
wsj.com/us-news/as-sig…
Read 4 tweets
Eric Topol Profile picture
Aug 14, 2025
As I wrote in SUPER AGERS, the immune system is the key to modulating our aging process and the opportunity to extend healthspan. Today @NatureAging 7 new articles, summarized here, that reinforce its central role
nature.com/articles/s4358…Image
Inflammaging: with aging comes untoward inflammation, a summary graphic
nature.com/articles/s4358…Image
The potential consequences of too youthful immune system in an older person —> autoimmunity
nature.com/articles/s4358…Image
Read 5 tweets
Eric Topol Profile picture
Aug 7, 2025
The new special issue @ScienceMagazine features Immunity with 4 outstanding review papers, 5★
Our immune system over the lifespan, sex differences, influence on physiology, and host antiviral defenses science.org/toc/science/cu…Image
Our immune system as we age: the path to immunosenesence and inflammaging
science.org/doi/10.1126/sc…Image
Sex differences science.org/doi/10.1126/sc…Image
Read 5 tweets
Eric Topol Profile picture
Jun 8, 2025
We've learned a lot more about the principal drivers of age-related diseases in the past few weeks. And that leads to a unified model to pull it all together. (open-access) Image
I review 4 new reports, summarized here:
1. The proteins from senescent cells predict age-related clinical outcomes
2. A new epigenetic age clock connects the dots between aging, the immune system, inflammation and lifestyle factors
3. People with a fast pace of aging had an increased risk of cognitive impairment, age-related diseases, disability, and mortality
4. The Importance of “Immune Resilience” for Healthspan
And present a unified I/I model for what we now know Image
Read 4 tweets
Eric Topol Profile picture
Apr 13, 2025
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground Truths (link in my profile d/t X-suppression)Image
Here's the response to exercise Image
The most sensitive and accurate biomarker to date Image
Read 5 tweets

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