prior infection isn't immunity,
it's a preexisting condition.
CoV damages ACE2 organs & immune system. It persists.
With ORF6 it suppresses immune response (by downregulating MHC1 & INFN)
With ORF8 it triggers T cell wear&tear.
(anergy, autoimmunity, less clearance, cancer)
concerning SARS-CoV-2 & #ORF6:
concerning SARS-CoV-2 & #ORF8:
concerning SARS-CoV-2 & #cancer:
concerning SARS-CoV-2 & #persistence:
one example: persistence in the gut
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