#Celiac disease with #CarolSemrad
#MedTwitter #GITwitter #ACG2022
Defining #celiac disease and non-celiac gluten (more accurately, wheat) sensitivity
#Celiac disease is common
#Celiac associations
Most #celiac disease patients have "atypical" symptoms
Rarely can present with acute severe abdominal pain from intussusception or bowel edema
Pathogenesis of #celiac disease: T-cell mediated
💡Lots of potential treatment targets!
Diagnostics
🧬start with anti-TTG IgA
💡For serology and biopsy, need to be eating gluten to avoid false negative
Caveats with #celiac serology
Endoscopy in #celiac disease
Histology of #celiac disease
Villous blunting is NOT specific to #celiac disease! (This is why we need serology)
Do we need a biopsy to diagnose #celiac disease? Not necessarily...
HLA DQ2/DQ8
💡NOT diagnostic, since up to 40% of healthy population has; good for EXCLUDING #celiac disease
Diagnosing #celiac disease when already on a gluten-free diet
Management of #celiac disease: gluten-free diet
🦴osteopenia/osteoporosis
🧫cancer
☠️mortality
Disease monitoring
What about ongoing symptoms on a strict gluten-free diet?
#Celiac disease summary
Share this Scrolly Tale with your friends.
A Scrolly Tale is a new way to read Twitter threads with a more visually immersive experience.
Discover more beautiful Scrolly Tales like this.