A master class on prokinetics from @NGMJournal! Here is a summary! 🧵👇
⚡️🎈〽️🪠🫀💩🚄🧠✳️🗯️💊📰🚽🔌🧪💡🧲📊🔎
#MedTwitter #GITwitter #motility #pharmacology
onlinelibrary.wiley.com/doi/full/10.11…
Pyridostigmine & neostigmine
⚡️cholinesterase inhibitors
🧠pyrido should not cross the blood-brain barrier
🚽evidence in chronic idiopathic constipation and acute colonic pseudo-obstruction
🫄pregnancy class C; excreted in breastmilk
🫀cholinergic side effects, esp bradycardia
Dec 15, 2022 • 20 tweets • 13 min read
I gave a talk on inpatient bowel regimens today for the @YaleMed@YaleIMed residents and students, with additional 💎s on outpatient #constipation. Here are the slides!
sciencedirect.com/science/articl…
💨The gut microbiota generates ~0.2L–1.5L of gas per day
💨>99%: hydrogen (H2), carbon dioxide (CO2), & methane (CH4)– *odorless*
💨foul smell of gas from <1%: sulfur–containing gases hydrogen sulfide (H2S), methanethiol (CH3SH), dimethyl sulfide [(CH3)2S] + volatile compounds
🎯 Goals in management of inflammatory bowel disease with @MLongMD
#MedTwitter#GITwitter#IBD#ACG2022
Only a minority of Crohn disease patients have an indolent course. The majority have PROGRESSIVE disease. We need to identify these patients and treat them in the window of opportunity.
Oct 23, 2022 • 17 tweets • 8 min read
Disorders of the hepatic and mesenteric
circulation