#MedTwitter #HemeBoards @HemOncFellows
🧵Summary of erythrocytes inclusion bodies:
1️⃣Howell-Jolly body
➡️composition: DNA
🔬associations: splenectomy, hyposplenism, megaloblastic anemia, hemolytic anemia, sickle cell disease
2️⃣Basophilic stippling
➡️composition: RNA
🔬associations: lead intoxication, thalassemia, abnormal heme synthesis
3️⃣Pappenheimer bodies
➡️composition: iron
🔬associations: splenectomy, hemolytic anemia, sideroblastic anemia, megaloblastic anemia, hemoglobinopathies
4️⃣Cabbot ring
➡️composition: remanent of mitosis spindle
🔬associations: MDS, megaloblastic anemia, AML
5️⃣Heinz body
➡️composition: unstable haemoglobin
🔬associations: unstable hemoglobin, G6PD deficiency and other erythrocytes enzyme deficiency, some hemoglobinopathies, alpha thalassemia
6️⃣Hemoglobin H
➡️composition: beta chain tetramers
🔬associations: a type of alpha thalassemia
End🧵
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