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Direct link to streaming and agenda: nextmed.health/live
@NextMedHealth agenda Mar 13-16 (times in PT): files.elfsightcdn.com/eafe4a4d-3436-…
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4/ Future applications of AI
5/ AI limitations
6/ AI: We don't wanna create chemical weapons, and we don't wanna perpetuate problems of the current medical system -> Do no harm & pay down tech debt
7/ On Web3 in healthcare
8/ ChatGPT is just a tip of the iceberg. We need a highly decentralized approach.
9/ From web 1 to web 3
10/ On decenralized science. Massive transformation is happening in the science space.
11/ How o we take AI to decentralized data? Aggregation, mining, reward, interact. True anonymity, not just pseudoanonymity.
12/ Pseudoanonymity -> privacy tech.
Utility vs. privacy.
Tradeoff as you go to the right.
Federated Learning & Split Learning
13/ Every hospital can create local AI, but those are imprecise. (What works on children may not work on elderly. What works on smokers may not work on nonsmokers) -> creating collective intelligence
14/
15/ HealthUX.
Friction in EHR (e.g. patient matching - recognizing correct patient when multiple have the same name)
Decentralized science and AI
16/ More on decentralized society w/ web 3 - see the QR code
17/ Surgeon and XR enthusiast @ZGJR is now on stage at @NextMedHealth. Join livestream here: nextmed.health/live
18/ Augmented Relity (AR) - Mixed reality (MR) - Virtual reality (VR)
Hololens
Multi-user experience from different geographical locations
19/ Learn how to diagnose etc. from extended reality. Multiuser training.
Sensory integration including haptics
Cost has been decreasing
20/ Platform: must be multi-player, scalable, AI powered, cost-effective
Haptics glove helps you feel what you're touching to make it more real.
21/ VR: can smell (e.g. while learning to make pizza).
Strong potential: PTSD and smelling powder
Manipulate data real time in 3D
Improving flow and experience in a surgery
22/ Bringing anatomically correct images to EMR
23/ Blue pill or red pill? ;)
24/ Q (@daniel_kraft): Who can be a surgeon w/ the new technology?🤔
A (@ZGJR): Technology can bring education to anywhere anytime in a cost effective way to anywhere in the world...
25/ 🎶Highway to hell ➡️ Highway to heal. @acdc music w/ lyrics rewritten for medical field🩺🎸💡
26/ Chris Wigley on genomics
Sequenced kiddo Jessica (4yo) and both parents to get an effective treatment.
27/ Population health study. Clinical reasons to be using whole genome studies: many patients not diagnosed through other means
28/ Massive proof of concept study for genomics in healthcare
Numerous partners
29/ Whole genome sequencing. Green: piloting, trying to bring into clinic. Scicence -> pilots -> innovation -> clinical care
30/ Productivity challenges. Appmnts can be reduced. Finding right therapeutics for cancer patients.
Like acquarium: study but don't take it out.
Only valuable when joined w/ other modalities.
Scanning & digitizing data from cancer patients -> the largest dataset of its kind
31/ Kiddo w/ inconclusive tests. Genom determined that his tumor was benign.
32/ They have the lead scientists to lead the discoveries
33/ Lifelong relationship w/ the genome: how can that accelerate the right treatment?
E.g.
Teenager: mental health
Later: neurodegenerative diseases
34/ Genomics England to transform lives on scales and demonstrate the concept
35/ Andrew Hessel on Synthetic Biology: Rewriting Life.
= intersection of life science, computation and automation
36/ DNA sequencing cost is outpacing Moore's Law
27/ Identify which dog has been pooping on your lawn 😂💩🐕🦺
28/ Numerous applications: anything that touches life, including degradable plastics....
29/ Positive feedback loop.
AI tools to design proteins.
Labs are becoming automated.
40/ Protein engineering.
Can grow cells on chips and train it to play pong.
Will be able to engineer vectors and viruses.
Kill cancer cell... -> treat cancel in an individualized way
Cancer vaccines for patients.
41/ We'll need bigger investment in biosecurity.
Extinction...
Can we stop aging, or even become immortal?
43/ Will our bedrooms look like this in 20-30 yrs?
44/ On new frontiers in women's health. Female animals and humans were not included in clinical trieals until quite recently. It's also a funding problem.
45/ #Ovaries age 2.5x faster than the rest of the body -> puts #women in distinct disadvantage. Ovarian health is very important for overall women health.
46/ 1000 eggs are lost month, 1 of which may or may not get fertilized.
Line between puberty and menopause: if we can change theat -> can change how women age -> @OvivaTx
Hormonal changes associated w/ #menopause speed up cellular aging by 6%
47/ Women w/ later menopause tend to live longer.
48/ Eternal fertility in naked mole rats
49/ #AMH
Regulates how often and how many eggs released to maturation pathway
-> can regulate the pace at which we deplete the ovarian reserves?
50/ Possible fertility and IFV help.
Can double # (ovulated?) eggs w/o reducing quality
Validating - lots of info we don't know. Humans aren't rodents.
51/ Goals: Learn more about women's (ovarian) health. Raise awareness. Uncover unanswered questions. Train docs better.
Ultimately: give women choice!
Learn more on @OvivaTx website.
52/ Mariya Filipova on Systemic Health: healthy patient outcomes communities
Do you think about dentist when we mention overall health? Oral health is overall health! Related to many other health aspects.
Untreated oral health issues -> higher risk of dementia & cognit. decline
53/ Neither painkillers nor antibiotics treat the underlying issue.
🦷Also equity issue: more likely to have
Dental care is outpacing the growth of healthcare costs
54/ Access to florinated water
Toothbrushes: electric prototype from 1937 similar to today's toothbrushes
Patient experiences and outcomes haven't changed much
55/ Providing funding to companies that improve link dental care and link it to overall health.
@vVardisofficial: Peptide that regenerates enamel.
Future: instead of drilling & filling may be able to ("rebuild"?)
56/ Accelerator w/o giving up equity
57/ 🦷innovative companies examples:
Saliva-based diagnostics to screen for dental cancer early
Future: Connecting medical & dental teams. Coordinated & integrated treatment plan.
58/ COmpany w/ enamel regenerating product weren't initially able to get reimbursement b/c there was no code. Recently passed new CDT code. Need collaboration b/w investors, companies and regulators. Their accelerator is accepting applicatoins!
59/ Session 4: Transforming tech & patient voice into empathy, impact & access.
@lucienengelen: "From What's New, to How To"
60/ Don't fix the hole, reach out to the main tap!
61/ By 2035 we'll have a problem in healthcare
62/ Do we add digital? Or digital first?
It's about user interface, yourself.
If possible, do it yourself, at home, digitally.
63/ Possible new Moore's Law: doubling intelligence in the universe
64/ World's first autonomous robot
65/ "How are you doing?" - "Great! Slept well & have a great EKG!"
66/
67/ Consumer is awakening. The consumer is your patient.
Why aren't we utilizing supermarkets? -> Healthcare meets retail.
68/ Maybe we'll have new tech @ retail places
69/ Healthcare is next!
70/ Non-healthcare players in healthcare
71/ Every citizen wil have own data. Better diagnostic and treatment.
72/ Healthcare: delocalized, democratized, digital
73/ Joyce de Ruiter: Patients Included: Agility & Resilience in Times of Change
74/ Wow - thank you Joyce de Ruiter for sharing on your rare disease experience with Usher syndrom related to loss of both vision and hearing
75/ A brief conversation can make a huge difference to a patient.
Always choose words of empowerment.
Wow, Joyce de Ruiter - such an overachiever and an inspirer despite of your diagnosis!
76/ PDOH: "Political determinants of health"
Alister Martin: "At the intersection of healthcare, policy & civic engagement"
77/ DYI: Voter registration is legal in healthcare settings (as a proof of residency in Massachusets)
"Why aren't you registered to vote?" - "Noone has ever asked me"
78/ Low voter turnout & low life expectancy are correlated
79/ Vote to have perspectives included in politics and when important decisions are being made
80/ Doctor's questions: Do you smoke? Do you drink? Are you registered to vote?
Posters and discharge papers helping patients to vote.
Patient registered to vote -> got home, and also helped her family to register to vote.
81/ They helped 80k patients to register to vote, w/ turnout 85% (higher than general population of 66.8%) Most pronounced on low propensity voters.
82/ Voting = SDOH!
They helped w/ HHS & VA
Upcoming 2024 registration -> opportunity to get patients involved in voting! cc @poppy_northcutt
83/ Physicians voted 9% lower than general population
84/ Healthcare workers can help created democracy and increase # registered voters and voter turnout. More info: vot-er.org
85/ Magical interlude w/ a Robert Strong - commedian & magician
---
Power of Story w/ Dave Zaboski
86/ @Deloitte folks on stage: Bori Kheyn-Kyeyfets & Simon Gisby on "Platforms & The Reassembly of Care"
Sick care -> health care -> wellness (well care)
87/ Ecosystem focused on us: my healthcare meets
Covid times: we turned healthcare workers into gig workers who can work from another locations!
Platforms will take us from fragmentation to reassembly
88/ We'll need a "platform mindset": navigating patients - members - consumers
Fee for service -> value based care
Health systems, med tech, pharma: point solutioning companies are not driving this transformation
$40B flowing VCs -> different diseases => to merge & aggregate
89/ How do you balance personalization?
Retina: unique identifier. Who owns "Clear"? Are we willing to give up data w/o knowing who owns the data to save a few min and not to take off our shoes at the airport?
90/ Andrea Kates on Finding Your Next
91/ There is no try. Only do. ☯️
Take concrete steps towards game changing actions.
92/ Get to the next concrete steps!
93/ Jemie Metzl: The promise and peril of human genome editing.
Author of Hacking Darwin: Genetic Engineering & the Future of Humanity.
Member, WHO expert advisory committee on Human Genome Edicting
94/ Jamie Metzl predicted that gene editing would happen soon and that it would happen in China
95/ Estimating 13 new genes therapies to be approved this year (2023)
Photo from 3rd international summit on gene editing w/ Victoria Gray - see the attached quote!
These technologies: unlimited potential to "do good"
96/ Promises:
- Heritable diseases
- Times when we'll be able to treat everything
- Even at or before pre-implanted embryo
- Therapy vs. enhancement: part of the same continuum.
- Expecting discussions: what's ok?
- Living in space? Athletics?
97/ Real dangers, fears, origins of covid and book tips
98/ Interconnected ecosystems.
We each have a role.
Let's do what we're doing as ethically as possible.
99/ Med scrubs for attendees! Also encouraging to install BINAH.ai app for tomorrow.
100/ Closing keynote from day 1: by legend Leroy Hood Md PhD: "The transition from genomics to phenomics in precision population health"
Why health?
Health started w/ the Greeks.
Using data-driven systems
Blood = window into wellness & disease: Molecules concentration changes
101/ 1M person project over 10 yrs
1. Arivale (body) company he co-started
2. Partnering w/ Posit (brain)
3. Gut microbiome
Nearly 30 studies on wellness
103/ For most chronic diagnoses (cancer or diabetes): we have subtypes, then we can define nature of the subtype trajectory.
Health: welness - transition - disease
104/ Partners
105/ Will generate at least 1000x more data than initially
Recommendations how to optimize;
EHRs
SDOH
Whole genome analysis
106/ 2 knowledge graphs:
1. Google (50B nodes such as genes, proteins, gene diseases)
2. Spoke: Smaller (27M) but more details
Creating a digital twin for type 2 diabetes
Context for hyperscale AI
Mechanistic / causal
107/ How to persuade HCP, payer, politician, patient to buy into this?
Solution: prediction & prevention is going to save $Ts
Medical schools skeptical in trying new things.
Innovative healthcare 20module 1yr course for hs students
Upcoming book & documentary on wellness
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