KEY STUDY from @VirusesImmunity
DISTINGUISHING FEATURES of long COVID identified through IMMUNE PROFILING
Fig. 1: Demographic and clinical stratification of participants with LC. nature.com/articles/s4158…
2) Fig. 2: Exaggerated SARS-CoV-2-specific humoral responses and altered circulating immune mediators among participants with LC.
3) Fig. 3: Participants with LC showed limited but selective autoantibodies against the human exoproteome.
4) Fig. 4: Participants with LC demonstrate elevated levels of antibody responses to herpesviruses.
5) Fig. 5: Biochemical factors differentiate participants with LC from the matched controls.
6) DISCUSSION
"Immune phenotyping of PBMC populations revealed that participants with LC had notably higher levels of circulating non-conventional monocytes associated with various chronic inflammatory and autoimmune conditions.
7) Moreover, the number of CD4+ T central memory cells was significantly reduced and the absolute number of exhausted CD4+ T cells was increased."
"We also showed that individuals with LC have elevated antibody responses against non-SARS-CoV-2 viral antigens ...
8) ... particularly EBV antigens. EBV viraemia occurs during acute COVID-19 in hospitalized patients and predicts development of persistent symptoms in the post-acute period"
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