Thread by @ejustin46

KEY STUDY from @VirusesImmunity

DISTINGUISHING FEATURES of long COVID identified through IMMUNE PROFILING

Fig. 1: Demographic and clinical stratification of participants with LC. nature.com/articles/s4158…

2) Fig. 2: Exaggerated SARS-CoV-2-specific humoral responses and altered circulating immune mediators among participants with LC.

3) Fig. 3: Participants with LC showed limited but selective autoantibodies against the human exoproteome.

4) Fig. 4: Participants with LC demonstrate elevated levels of antibody responses to herpesviruses.

5) Fig. 5: Biochemical factors differentiate participants with LC from the matched controls.

6) DISCUSSION
"Immune phenotyping of PBMC populations revealed that participants with LC had notably higher levels of circulating non-conventional monocytes associated with various chronic inflammatory and autoimmune conditions.

7) Moreover, the number of CD4+ T central memory cells was significantly reduced and the absolute number of exhausted CD4+ T cells was increased."
"We also showed that individuals with LC have elevated antibody responses against non-SARS-CoV-2 viral antigens ...

8) ... particularly EBV antigens. EBV viraemia occurs during acute COVID-19 in hospitalized patients and predicts development of persistent symptoms in the post-acute period"

Thanks for reading 🙏