Thread by @DrJackKruse

Know your history because you do not. When LDL rises it a symptom of someone who needs to go into the sun more to lower the LDL by converting said cholesterol to Vitamin D to optimize your immune function. It never requires a drug or diet to repair. PAD is caused by ALAN or a lack of sunlight.

Peripheral Arterial Disease = PAD = Atherosclerosis = a lack of UV light or too much ALAN or both.

UVB light improves systemic inflammatory diseases by modulating the adaptive immune system. This is huge for autoimmune conditions and chronic inflammatory processes found in all chronic diseases. It shows you that the paradigm of centralized dermatologists, lipidologists, and cardiologists is dead wrong.

CITES
ahajournals.org/doi/10.1161/AT…

2. Statins are mitochondrial toxins because of their effect on CoEnzQ10 and cytochrome C oxidase. There are many ways in which they increase coronary artery calcification. One way is depletion of NO due to poor light and Vitamin K2 production from the gut, another is lack of sun to control calcium flows, and another is direct arterial melanopsin damage liberating Vitamin A to cause intimal damage and a loss of arterial NO.

Sufficient production of vital biochemicals such as Geranylgeraniol (GGPP) is required to maintain endotoxin tolerance in macrophages in our arteries once the damage occurs. Macrophages are the hallmarks of CVD/Atherosclerosis, contributing to plaque development, inflammation, and the promotion of thrombosis. Geranylgeraniol is downstream of Mevalonate in the cholesterol synthesis pathway, and GGPP synthesis is inhibited by Statins, as is CoQ10 and K2. Vitamin K2 is the cofactor for matrix Gla-protein activation, which PROTECTS arteries from calcification.

Statin use is independently associated with increased calcification in patients, & using an animal model of hypercholesterolemia, we present a molecular mechanism whereby statins promote the calcification of atherosclerotic plaque. ahajournals.org/doi/10.1161/AT…

3. This is why people with high LDLs tend to have low Vitamin D's, high BP, PAD, and glaucoma. All link to a lack of UV light and too much ALAN.

4. The link is obvious when you look for it. Moreover, the older one gets the more sun you need because as humans age their heteroplasy rises naturally and this means less water production at cytochrome c oxidase to buffer melanin biology = MORE PAD

5. Now Nick Horowitz PhD a med student at harvard (huge DARPA place) has showed how eating Oreo's is better than a statin for lowering your cholesterol. Let that sink in. It tells you how FOS they have been. But you can keep believing the centralized lies.

6. Statins increases: Coronary Artery Calcium Score, promotes vascular calcification, and the plaque get harder
acc.org/latest-in-card…
nature.com/articles/s4151…
https://consultqd.clevelandclinic.o...coronary-atheromas-even-while-shrinking-them/
tctmd.com/news/statins-.…
The use of statins increases the calcific atherosclerosis in T2DM and increases risk of CVD morbidity and mortality - care.diabetesjournals.org/content/35/11/…

7. BigHarma lie they push to the masses: They pay for science to push th eidea of a benefical beneficial effects in primary and secondary prevention of CVD. That is engineered via the methodolgy of flawed design BigHarma controls.

What you should know: Statins, all of them, induce adverse effects, like myopathy because of how they damage lipid rafts in membranes. This lowers delta psi = less water production at cytochrome C oxidase.

. Mitochondrial dysfunction PLAYS THE KEY ROLE likely in the pathogenesis of these Harma induced adverse reactions due to damage to cytochrome c and comorbid CoQ10 depletion, inhibition of ETC complexes, depletion of mevalonate pathway end products, membrane depolarization and induction of intrinsic apoptosis, dysregulation of calcium metabolism, and fatty acid oxidation.

Chronic statin treatment has been associated with increased risk for T2DM and cognitive impairment. ; The widespread usage of these drugs was done for profit and the considerable prevalence of side effects we should require decentralized clinicians to better understand the underlying pathological mechanisms that BigHarma will never allowed to be carefully studied by a biophysicist. They are criminals.

8. Wake the fuck up folks.......No LDL at the site of damage. Guess what is in arteries linked to light related damage?

MELANOPSIN.

Yes. Light causes PAD too.

9. Melanopsin’s systemic distribution in our arterial system suggests that this normally rare signal was evolutionarily optimized for daytime use, not nighttime exposure. Today's most ignorant mammals have built a world were manufactured light has replaced sunlight.

The ubiquity of artificial blue light overwhelms this signal, diluting its informational value and causing widespread dysregulation, which causes the aftermarket disease we are seeing = THAT IS WHY PAD IS SO COMMON. Enjoy your screens and tech gear because BigHarma will get rich off your stupidity

10 @threadreaderapp make me a roll

11. The Failure of Cholesterol Lowering Drugs
In 2012, the FDA added the warning of possible memory loss to statin drug labels. Although the brain is only 2 percent of the body weight, the brain contains about 25% of the total body cholesterol.

Since the blood brain barrier (BBB) prevents cholesterol uptake from the bloodstream, the neurons in the brain must make their own cholesterol, called de novo synthesis. Unfortunately, statin drugs are designed to be charged and lipophilic like LNPs are so they can easily cross the blood-brain-barrier and block production of cholesterol in the brain. About 70% of the brain cholesterol is found in myelin sheaths of oligodendrocytes, and 30 percent in cell membranes of neurons and brain cells called astrocytes.

Cholesterol depletion in the hippocampus "leads to progressive loss of dendritic spines and synapses". Would you take a drug that prevents your brain from making essential cholesterol.