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☣️ Pleb Kruse = BTC foundationalist in exile 🟩🔆 Profile picture
@DrJackKruse
Mar 8 • 11 tweets • 7 min read • Read on X
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Know your history because you do not. When LDL rises it a symptom of someone who needs to go into the sun more to lower the LDL by converting said cholesterol to Vitamin D to optimize your immune function. It never requires a drug or diet to repair. PAD is caused by ALAN or a lack of sunlight.

Peripheral Arterial Disease = PAD = Atherosclerosis = a lack of UV light or too much ALAN or both.

UVB light improves systemic inflammatory diseases by modulating the adaptive immune system. This is huge for autoimmune conditions and chronic inflammatory processes found in all chronic diseases. It shows you that the paradigm of centralized dermatologists, lipidologists, and cardiologists is dead wrong.

CITES
ahajournals.org/doi/10.1161/AT…Image
2. Statins are mitochondrial toxins because of their effect on CoEnzQ10 and cytochrome C oxidase. There are many ways in which they increase coronary artery calcification. One way is depletion of NO due to poor light and Vitamin K2 production from the gut, another is lack of sun to control calcium flows, and another is direct arterial melanopsin damage liberating Vitamin A to cause intimal damage and a loss of arterial NO.

Sufficient production of vital biochemicals such as Geranylgeraniol (GGPP) is required to maintain endotoxin tolerance in macrophages in our arteries once the damage occurs. Macrophages are the hallmarks of CVD/Atherosclerosis, contributing to plaque development, inflammation, and the promotion of thrombosis. Geranylgeraniol is downstream of Mevalonate in the cholesterol synthesis pathway, and GGPP synthesis is inhibited by Statins, as is CoQ10 and K2. Vitamin K2 is the cofactor for matrix Gla-protein activation, which PROTECTS arteries from calcification.

Statin use is independently associated with increased calcification in patients, & using an animal model of hypercholesterolemia, we present a molecular mechanism whereby statins promote the calcification of atherosclerotic plaque. ahajournals.org/doi/10.1161/AT…
3. This is why people with high LDLs tend to have low Vitamin D's, high BP, PAD, and glaucoma. All link to a lack of UV light and too much ALAN. Image
4. The link is obvious when you look for it. Moreover, the older one gets the more sun you need because as humans age their heteroplasy rises naturally and this means less water production at cytochrome c oxidase to buffer melanin biology = MORE PAD Image
5. Now Nick Horowitz PhD a med student at harvard (huge DARPA place) has showed how eating Oreo's is better than a statin for lowering your cholesterol. Let that sink in. It tells you how FOS they have been. But you can keep believing the centralized lies. Image
6. Statins increases: Coronary Artery Calcium Score, promotes vascular calcification, and the plaque get harder
acc.org/latest-in-card…
nature.com/articles/s4151…
https://consultqd.clevelandclinic.o...coronary-atheromas-even-while-shrinking-them/
tctmd.com/news/statins-.…
The use of statins increases the calcific atherosclerosis in T2DM and increases risk of CVD morbidity and mortality - care.diabetesjournals.org/content/35/11/…
7. BigHarma lie they push to the masses: They pay for science to push th eidea of a benefical beneficial effects in primary and secondary prevention of CVD. That is engineered via the methodolgy of flawed design BigHarma controls.

What you should know: Statins, all of them, induce adverse effects, like myopathy because of how they damage lipid rafts in membranes. This lowers delta psi = less water production at cytochrome C oxidase.

. Mitochondrial dysfunction PLAYS THE KEY ROLE likely in the pathogenesis of these Harma induced adverse reactions due to damage to cytochrome c and comorbid CoQ10 depletion, inhibition of ETC complexes, depletion of mevalonate pathway end products, membrane depolarization and induction of intrinsic apoptosis, dysregulation of calcium metabolism, and fatty acid oxidation.

Chronic statin treatment has been associated with increased risk for T2DM and cognitive impairment. ; The widespread usage of these drugs was done for profit and the considerable prevalence of side effects we should require decentralized clinicians to better understand the underlying pathological mechanisms that BigHarma will never allowed to be carefully studied by a biophysicist. They are criminals.Image
8. Wake the fuck up folks.......No LDL at the site of damage. Guess what is in arteries linked to light related damage?

MELANOPSIN.

Yes. Light causes PAD too. Image
9. Melanopsin’s systemic distribution in our arterial system suggests that this normally rare signal was evolutionarily optimized for daytime use, not nighttime exposure. Today's most ignorant mammals have built a world were manufactured light has replaced sunlight.

The ubiquity of artificial blue light overwhelms this signal, diluting its informational value and causing widespread dysregulation, which causes the aftermarket disease we are seeing = THAT IS WHY PAD IS SO COMMON. Enjoy your screens and tech gear because BigHarma will get rich off your stupidityImage
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10 @threadreaderapp make me a roll
11. The Failure of Cholesterol Lowering Drugs
In 2012, the FDA added the warning of possible memory loss to statin drug labels. Although the brain is only 2 percent of the body weight, the brain contains about 25% of the total body cholesterol.

Since the blood brain barrier (BBB) prevents cholesterol uptake from the bloodstream, the neurons in the brain must make their own cholesterol, called de novo synthesis. Unfortunately, statin drugs are designed to be charged and lipophilic like LNPs are so they can easily cross the blood-brain-barrier and block production of cholesterol in the brain. About 70% of the brain cholesterol is found in myelin sheaths of oligodendrocytes, and 30 percent in cell membranes of neurons and brain cells called astrocytes.

Cholesterol depletion in the hippocampus "leads to progressive loss of dendritic spines and synapses". Would you take a drug that prevents your brain from making essential cholesterol.Image

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More from @DrJackKruse

☣️ Pleb Kruse = BTC foundationalist in exile 🟩🔆 Profile picture
Oct 28
Fun fact: your heart isn’t the first organ to age…

Your arteries are.

Because they are closer to the surface where the light is.

That is where the man made light is that causes this.

This melanopsin damage raises heteroplasmy rates and that ages your arteries rapidly.

UV light increases arterial longevity and lowers heteroplasmyImage
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2. PAD is all about light. threadreaderapp.com/thread/1898445…
3. forum.jackkruse.com/threads/periph…
Read 4 tweets
☣️ Pleb Kruse = BTC foundationalist in exile 🟩🔆 Profile picture
Oct 25
Break all the centralized chains that bind you from living an epic life. Image
2. Become unmanageable for the government. For example, make your tax returns look like this every year the rest of your life and send it in certified mail. It forces them to have to accept it and lug it around. This is the 25th year I have done this in October. If each person did this in the USA, we would demolish the IRS with our behavioral inefficiency. Do not allow them to automate anything.Image
3. Bitcoin has a better chance of surviving a complete shut down of the internet than you bank does but few realize this. Fiat is the most unsafe shitcoin. Image
Read 10 tweets
☣️ Pleb Kruse = BTC foundationalist in exile 🟩🔆 Profile picture
Oct 23
1. Today's PSA: Image
2. Hi Jack,

Wondering if you'd be able to break down what happened after I took Venlafaxine (Effexor) a few years ago and if there's any specific things needed to be done to hopefully repair any damage.

After what I believe was a spontaneous CSF leak that happened one night and started all my chronic issues I was diagnosed with vestibular migraine around 3 months later.

Venlafaxine 75mg was indicated for this so I was on it for around 12 months (give or take the 3 months wean I did).

Within 3 weeks my emotions went numb, I lost my libido, erections and ability to pretty much feel love or any strong emotion. There was a very definite and obvious "change" but I believe I still had the ability to focus and enjoy hobbies etc.

After deciding to taper off, I would get brain zaps and all the other jazz that comes with it. After fully tapering, I was then introduced to anhedonia. Unable to feel or enjoy anything, unable to focus on anything for too long without getting the irritable and feeling like I need to do something else etc. Essentially feel there's been a permanent change since starting this.

This has improved slightly but not even close to where I'd like to be. Add all the daily brain fog, memory lapses etc and my brain is running on empty.

Does this need anything specific additional to the core light, water & magnetism?

Listening to this months webinar (October 2025) you mentioned accutane extending recovery from 6 months up to 5 years. This prompted me to ask this question and about my accutane use in the future as this is a huge jump in recovery time and shows how powerful these drugs are.
3. Reasons Why Venlafaxine Could Cause Issues, Based on My Thesis

My thesis posits that life's core "code" resides in conserved correlations of phase, spin, and topology, geometric invariants that maintain coherence beyond mere voltage gradients. Man-made electromagnetic (EM) pollution disrupts this coherence, leading to health risks like aging, cancer, and failed regeneration. Voltage is merely a "courier," while true memory and form emerge from photonic organization of spin and topological symmetry.

Venlafaxine, as a synthetic molecule introduced into this already polluted EM environment, would act to exacerbate disruptions by interfering with biological EM phenomena. Below, I list hypothesized reasons grounded in its structure, spectra, pharmacology, and potential EM interactions.

These are hypothestical extensions based on my published framework, drawing from known drug effects and bio-EM principles (e.g., biophotons, ion flows, and field coherence), while acknowledging that direct studies on venlafaxine-EM-biology intersections are limited because BigHarma isn't going to dump on its own product with truthful decentralized science.Image
Read 20 tweets
☣️ Pleb Kruse = BTC foundationalist in exile 🟩🔆 Profile picture
Oct 20
Hey stop chewing your steak and read some real science. You spread nothing but half truths.

You are and always have been a smooth brainer orthopod. you want some respect.........

Do some real lifting. Read real science and understand how it all really works.

Simplicity, many think it is always the path to the answer to what defines longevity. I usually ask these people to explain the parsimony of parity violation and how it explains life and I get blanks stares from meat heads like you.

linkedin.com/pulse/how-life…

There is always time, when you create time by providing energy for things to manifest. Humans are the universe in miniature, almost a caricature of nature’s full complexity. Human reality is like fog on a bathroom mirror. Its presence incites you to wipe the mirror, and try again until you get what you want. This makes human reality a fluid concept, at best a misnomer linked to the energy in the process. As energy varies so does the reality we experience. This is what creates our differences of opinion. Reality is not uniform for man. Reality just does not exist unless we are observing it. Man takes reality for granted because it is all he really knows, because it is what he sees; it is a riddle wrapped in a mystery rolled into an enigma, and buried in paradox. The reality we feel is thatt we all die, but the goal of nature wasn't that we'd live forever. Her goal is to create something that can sustain itself. The reality is our children are just perpetual motion machines from the past given to the present changed by the light they get. This means reality today, is principally constrained by its past (mtDNA) and the future flows of energy from the solar environment.

You have never realized what I was up to in that QUILT document then, so it makes sense that right now, you have zero clue what I am doing, but later you will understand........what I buried in that document.

The answer to how life operates is between every word I penned.
2. How do these pieces fit? Image
3. In order to prove experimentally the existence of magnetic current for the first time, researchers mapped Onsager’s 1934 theory of the movement of ions in water onto magnetic currents in a material called spin ice. I have introduced you to Onsager reciprocity relationship before in the blog. It describes how ions flow naturally below their molecular order. It describes how ions flow in relation to other things around them. In the lab, scientists tested the theory by applying a magnetic field to a spin ice sample at very low temperatures and observed the process using muons. I believe this process can also use pions. Muons and pions are parts that can make electrons and protons when they are in a place where a rogue element is present under extraordinary electric and magnetic fields. They can create other possible quantum possibilities for protons and electrons within mitochondria by creating something called an “exotic atom”. This atom would be a transitional state atom to enable changes in information and energy to occur without much thermodynamic cost. This happens inside the matrix of mitochondria.

Pions and muons allow for atoms to remain the same element on the periodic table but get lighter atomically in their mass. Anything that gets lighter becomes more favorable energetically by mass equivalents.

An exotic atom is an otherwise normal atom in which one or more sub-atomic particles have been replaced by other particles of the same charge. For example, electrons may be replaced by other negatively charged particles such as muons (muonic atoms) or pions (pionic atoms). Because these substitute particles are usually unstable, exotic atoms typically have very short lifetimes. Today's technology therefore cannot measure them. Because they are charged, they are controlled with infinite range and power by the electromagnetic force. This is the force we see acting within the mitochondria and in the sun.
Read 9 tweets
☣️ Pleb Kruse = BTC foundationalist in exile 🟩🔆 Profile picture
Oct 18
1. The terms anaplerosis and cataplerosis describe reciprocal and correlative reactions involved in the function of the TCA/urea cycle. The enzymatic steps in these processes have long been known, but the overall concept of a linkage between anaplerosis and cataplerosis should be underscored because the balance between these two processes controls the entry and exit of TCA cycle anions.

Anaplerotic and cataplerotic reactions are involved in the ultimate disposal of all metabolic intermediates. The metabolic role of anaplerosis and cataplerosis in amino acid metabolism varies with the light environment, specific organs and is dependent on the nutritional/metabolic status of the individual.

If the AM sunrise is seen by the eye, skin, and sensed by the gut via the skin clocks, during feeding, the intestine is an important site of catabolism of enterally derived amino acids, whereas in the starved state amino acid catabolism occurs primarily in the kidney, liver, and muscle. The light environment is critical in how anaplerosis and cataplerosis operate in people.

Every tissue differs in how it uses anaplerosis and cataplerosis.This implies the regulation of anaplerosis and cataplerosis is very dependant on deuterium kinetics in the matrix from normal or abnormal metabolic and physiologic states.

Methionine: Propionyl-CoA forms as a catabolite of methionine, threonine, and the branched-chain amino acids. β-Oxidation of fatty acids with an odd number of carbon atoms yields propionyl-CoA. The oxidation of the side chain of cholesterol also yields propionyl-CoA. Thus, propionyl-CoA is derived from the catabolism of lipids and proteins.Propionyl-CoA is converted to succinyl-CoA, which is oxidized or converted to glucose by way of oxaloacetate and pyruvate. Succinyl-CoA may also form δ-aminolevulinate, a precursor of porphyrin biosynthesis.

This is critical in oncogenesis because cancer cells need brisk ECT which means that cancer cells can use methionine to usurp oxygen using methionine to increases both angiogenesis and hemoglobin production to make sure that oxygen delivery is brisk and apoptosis stays inhibited PROVIDED VDR/D3 and/or UVA are absent to slow ECT flow.

NO is used to slow ATPase as a braking mechanism when oxygen is a toxin. This is a remnant from our GOE evolution before heme proteins and melanin were innovated to protect us as a firewall from oxygen. NO is liberated by UVA light and NIR.

Update your biochemical models because they are all broken.Image
2. Anaplerosis and Cataplerosis: They are Light-Dependent Gatekeepers of TCA/Urea Cycle Dynamics and Metabolic Fate

From first principles, metabolism is fundamentally an energy and information flow process, governed by thermodynamic gradients where sunlight provides the primary low-entropy input to drive organization and efficiency.

The tricarboxylic acid (TCA) cycle, also known as the Krebs or citric acid cycle, serves as life's central hub for oxidizing nutrients to generate ATP, but it doesn't operate in isolation.

Anaplerosis (replenishment of TCA intermediates like oxaloacetate or succinyl-CoA) and cataplerosis (removal of these intermediates for biosynthesis or disposal) act as reciprocal OPTICAL valves, ensuring the cycle's continuity while adapting to cellular demandsImage
3. Ultimately, these processes dictate the disposal of all metabolic intermediates, linking carbon, nitrogen, and sulfur flows across pathways like amino acid catabolism, fatty acid oxidation, and urea cycle.This balance controls the entry and exit of TCA anions (e.g., citrate, malate), preventing depletion during high biosynthetic pulls (e.g., gluconeogenesis, lipid synthesis) or overflow during nutrient excess.

Ultimately, these processes dictate the disposal of all metabolic intermediates, linking carbon, nitrogen, and sulfur flows across pathways like amino acid catabolism, fatty acid oxidation, and urea cycle.Image
Read 19 tweets
☣️ Pleb Kruse = BTC foundationalist in exile 🟩🔆 Profile picture
Oct 15
There is only one kind of shock worse than the totally unexpected outcome: the expected for which one has refused to prepare. This is the new jouney for those who complied with tyranny and joined the experimental group the last 5 years.

The expected always happens and this can be a problem too. Sometimes the most scenic roads in life are the detours you didn't mean to take. This is true for the control group.

The results of traveling the road less traveled surprises us. So, would you really like to know your future?

If your answer is yes, think again. Not knowing is the greatest life motivator for thriving for those of us who rejected compliance.
So enjoy, endure, survive each moment as it comes to you in its proper sequence -- a surprise. Embrace the chaos and the suck for a change, but never comply with tyranny.Image
2. People who complain they have no time or wish they could control how they spend their time to do what they should are stuck in a low dopamine state because of the light they live under. Few of them are aware of the implications.

Here is how it works: Know how to get the most results in the least amount of time. That’s the ultimate aim of productivity skills. Savages know we all have the same amount of time in a day so when somebody tells you they do not have time to do something they have a made choice with their time to do something else. In the age of information, ignorance of the wisdom of reality and nature is a choice.Image
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3. With that said how come equatorial Africans never seem to get cancers on the equator when they make the daily choice to be in the strongest sun on the planet possible, but people who have no time because they are working under fake light and nnEMF seem to get all denovo or jab induced cancers, and especially the worse types?Image
Read 5 tweets

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