Published today! Victoria Bastos, @KerrieGreene_ et al found two distinct immunotypes of ME/CFS based on the cerebrospinal fluid analysis. Great collaboration with @MBVanElzakker @microbeminded2 and the Bragée clinic in Sweden. (1/)
academic.oup.com/jimmunol/artic…
This is perfect timing as Victoria will present these data at the @polybioRF symposium today. (2/)
polybio.org/spring-2025-sy…
Based on cerebrospinal fluid cytokines, we identified two clusters of ME/CFS patients. Cluster 1 had elevated matrix metalloproteinases & many cytokines compared to cluster 2. Other than older age (Cluster 1), clinical presentation of these clusters was similar. (3/)
While we do not know why some people with ME/CFS have elevated MMPs and cytokines, our data suggest potentially distinct drivers of disease that manifest in similar clinical phenotypes. Future studies are needed to probe therapeutic pathways suitable for these clusters. (4/)
Congratulations to all the authors for this important work 👏🏼👏🏼👏🏼 We thank @weandmecfs @polybioRF and Carol Cirot Foundation, NIH and @HHMINEWS for supporting this work, and for all the patients for heroically donating CSF for our research 🙏🏼 (end)
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