1/ This is a thread on the results from #LOCOME project (links at the end) which involved work by @precisionlifeAI. Excited to say once again that when different methods identify the same "hotspots", it raises our confidence about these findings. Let's see why :
2/ In the study by @precisionlifeAI a total of 259 genes were identified as core genes as shown below. Observe the associations discussed (Inflammation, Cellular stress response etc). The question is : What can we make out of this gene subset? cc @Michaeltikus
3/ Here is a snapshot of these genes with some of them being annotated. The annotated ones are ABCA1, CYP7B1, CH25H, ABCC6, UGGT1
4/ From my presentation at EUROMENE (2018) : ABCA1, CYP7B1 note also the term "Oxysterols"
5/ Looking at CH25H, why is it important? I hypothesize it is a key aspect of impaired immunity but immunologists are the ones who should be looking at this : see where CYP7B1 and CH25H are located (also from my presentation in 2018) :
6/ In an interview by @CortJohnson I explicitly mentioned CH25H as well as Ubiquitination (also later confirmed on another study) : Link of interview : healthrising.org/blog/2023/10/2…
7/ Moving on now to ABCC6. Some tweets :
8/ Another finding from this study points to brain synapses and glutamate. Other associations with calcium metabolism which have been mentioned during today's presentation by @precisionlifeAI , I have also seen and are confirmed. Probably relevant to mitochondria.
9/ As I mentioned many key areas are coming together and hopefully I shared an example on how we should be working to make sense of these genes. I am preparing a presentation with latest updates and key areas to focus our research efforts, will post soon. UGGT1 is part of it.
10/ Link of study : medrxiv.org/content/10.648…
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