And just today this new study further challenges the sterile #placenta! π This team identified R. insidiosa as a bona fide resident at the placental basal plate..by using species-specific FISH probes to confirm + localize R. insidiosa within basal plate tissue specimens at term
https://twitter.com/MysorekarLab/status/1157719498176303104
1/1 From paper π βWe show that R. insidiosa is a bona fide resident in human #placental basal plate. It can access trophoblast cells in culture and within basal plate tissues where it localizes to intracellular single-membrane vacuoles and can replicate...β
2/2 β...However, the presence of R. insidiosa does not cause cell death and does not induce a pro-#inflammatory immune response suggesting that it is not harmful in and of itself...β
3/3 β...Finally, we show that in a pregnant mouse model, R. insidiosa traffics to the #placenta via the intrauterine route but does not induce preterm labor or preterm birth...β
4/4 β...Together, our findings provide a foundation for understanding non-pathogenic placental cell-#microbe interactions and the functional importance of R. insidiosa in #placental health and physiology.β
β’ β’ β’
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