Discover and read the best of Twitter Threads about #inflammatory
Most recents (17)
Back to basics‼️
A tweetorial on a clinical approach to #joint #pain 🪡
1/n
The 🔠ABCDE approach
🅰️ Articular (or not!) 🦴
🅱️ Background (& burden) 🎒
C Chronology 🕰️
D Distribution 📍
E Extra-articular 🍂
Let’s dive deeper
#MedTwitter
#RheumTwitter
A tweetorial on a clinical approach to #joint #pain 🪡
1/n
The 🔠ABCDE approach
🅰️ Articular (or not!) 🦴
🅱️ Background (& burden) 🎒
C Chronology 🕰️
D Distribution 📍
E Extra-articular 🍂
Let’s dive deeper
#MedTwitter
#RheumTwitter
2/n
#Pain is #inflammatory if worst in the AM/ after rest
#Swelling which is not bony #Synovitis the sine qua non of #inflammatory #arthrits
#Stiffness esp in AM & > 1 hour
“How do you feel when you wake in the morning?”
is a great question to ask
#MedTwitter
#RheumTwitter
#Pain is #inflammatory if worst in the AM/ after rest
#Swelling which is not bony #Synovitis the sine qua non of #inflammatory #arthrits
#Stiffness esp in AM & > 1 hour
“How do you feel when you wake in the morning?”
is a great question to ask
#MedTwitter
#RheumTwitter
3/n
🅱️ = BACKGROUND
Age 🕰️
Gender ♈️♎️
Race 🧕🏻
#Comorbidities
Pregnancy🤱🏻
And 🅱️ = Burden👩🏻🦼
#impact of disease
#MedTwitter
#RheumTwitter
🅱️ = BACKGROUND
Age 🕰️
Gender ♈️♎️
Race 🧕🏻
#Comorbidities
Pregnancy🤱🏻
And 🅱️ = Burden👩🏻🦼
#impact of disease
#MedTwitter
#RheumTwitter
✨ We're delighted to present a new Special Issue on Human #Bcells!
Guest edited by @BemarkMats, @JoSpencerLab & @Thomas_J_Tull, this collection explores the complexity of #Bcell development & function
Explore the articles below 🧵 & read for free ➡️bit.ly/40O6Onh
1/10
Guest edited by @BemarkMats, @JoSpencerLab & @Thomas_J_Tull, this collection explores the complexity of #Bcell development & function
Explore the articles below 🧵 & read for free ➡️bit.ly/40O6Onh
1/10
As well as #Bcell subtypes in health & inflammatory diseases, this collection also examines aspects of B cell diversity depending on #immunoglobulin isotype & in a microanatomical context
Our guest editors introduce the series in this Editorial 👇 2/10
academic.oup.com/cei/article/21…
Our guest editors introduce the series in this Editorial 👇 2/10
academic.oup.com/cei/article/21…
Rebekah Velounias & @Thomas_J_Tull @KCLImmunoMicro kick off the series papers with a discussion of B cell subset classification & their changes in #inflammatory disease 3/10
academic.oup.com/cei/article/21…
academic.oup.com/cei/article/21…
#GO #GraphiteOxide "#GrapheneOxide"
#Toxicity: physical #destruction, #oxidativestress, #DNA damage, #inflammatory response, #apoptosis, #autophagy and #necrosis.
en.wikipedia.org/wiki/Graphite_…
Pat: #CN112220919A for #2019nCov '#Vaccines' #Graphene Lipid Nanotech
#Toxicity: physical #destruction, #oxidativestress, #DNA damage, #inflammatory response, #apoptosis, #autophagy and #necrosis.
en.wikipedia.org/wiki/Graphite_…
Pat: #CN112220919A for #2019nCov '#Vaccines' #Graphene Lipid Nanotech
#Graphene in '#vaccines.'
Who is Pablo Campra #Madrid, the scientist who directs the research? | 07 Jul 2021
- Pablo Campra Madrid , a graduate in biology, a doctorate in chemical sciences and a full professor at the University of Almería #SoyUAL
Who is Pablo Campra #Madrid, the scientist who directs the research? | 07 Jul 2021
- Pablo Campra Madrid , a graduate in biology, a doctorate in chemical sciences and a full professor at the University of Almería #SoyUAL
Recent progress of #GrapheneOxide as a potential '#vaccine' #carrier and #adjuvant | Aug 2020
- functionalized graphene oxide serves as a vaccine #carrier and shows significant adjuvant activity in activating cellular and humoral immunity.
- functionalized graphene oxide serves as a vaccine #carrier and shows significant adjuvant activity in activating cellular and humoral immunity.
1/6 Interesting work from Dr. William Encinosa and colleagues, with #Black #children disproportionately affected...
#complications #adverse #drug #events #costs #disparities #multisystem #inflammatory
#syndrome #MISC #children #COVID19 #LongCovidKids
jamanetwork.com/journals/jaman…
#complications #adverse #drug #events #costs #disparities #multisystem #inflammatory
#syndrome #MISC #children #COVID19 #LongCovidKids
jamanetwork.com/journals/jaman…
2/6 "Did outcomes vary by the number of organ systems affected in #multisystem #inflammatory #syndrome in #children (MIS-C) in 2021?"
3/6 "In this cross-sectional study of 4107 #MISC #hospitalizations, as the number of #organ #systems affected increased from 2 to 6 or more, mortality increased from 1% to 6%, length of stay doubled from 4 to 8 days,..."
1/4 "Using droplet digital PCR, we found #SARSCoV2 #nucleocapsid #RNA in 7 out of 9 #adenoid and 15 out of 22 tonsil formalin-fixed, paraffin-embedded tissue blocks from post-COV individuals, despite #negative #nasopharyngeal swab #PCRs at the time of surgery..."
#pediatric
#pediatric
2/4 "... variation in memory B cell frequencies and serum-neutralizing antibody titers we observed further highlighted heterogeneity of responses that may leave some #children prone to #repeat #infection."
#pediatric #viral #persistence despite #negative #nasopharyngeal #PCR
#pediatric #viral #persistence despite #negative #nasopharyngeal #PCR
3/4 "... activated cells in these #tissues after infection may also contribute to delayed or #prolonged #sequelae of #COVID19, including long-COVID-19 and #multisystem #inflammatory syndrome in children,..."
#LongCovidKids #PASC
#LongCovidKids #PASC
#1 #Covid19 #Supplement thread for #LongCovid #LongHaul #PostCovid. This may help, if you suffer from #fatigue #brainfog #jointpain #inflammation #weakness #depression #anxiety #SOB #clots #fibrosis #myocarditis #heartattack #stroke #alz #memory frontiersin.org/articles/10.33…
#2 B-COMPLEX/MULTI VITAMIN. Buy a liposomal or other form that increases bio-availability. Take 1 capsule w/Breakfast and Lunch. If you have stomach upset, try sublingual (under tongue) EZ Melt B-Complex in AM & Multi w/iron for Dinner. amazon.com/Liposomal-Meth…
#3 OMEGA 3s. Fish Oil, Krill Oil, Algae Oil are all good sources of Omega 3. Be careful the EPA/DHA ratio. EPA helps with inflammation/DHA helps with cognition. You need both! Opt for a 1:1 or 2:1 ratio of DHA to EPA (2:1 ratio eg. 800 DHA/400EPA) amazon.com/3Care-Concentr…
#location location location: thrilled to share our work @CellCellPress! #interferons dictate #COVID19 severity! Specific #IFNs are produced along the #airways in response to #SARSCoV2 and drive protective or detrimental #transcriptional programs! 1/7 doi.org/10.1016/j.cell…
In a meeting I watched today, microglia priming was mentioned in #LongCovid and #ME/CFS. It’s important to clarify what “microglia priming” means. Microglial priming does not mean that after a trigger has “cleared” microglia remain perpetually activated
2/ Instead, microglia priming goes like this 👉 When microglia or other glial cells detect #infection, injury, or inflammatory mediators, they enter a state of activation in which they change morphology and release their own neuroexcitatory inflammatory mediators
3/ Then, after activating, they retain a “primed” functional state which causes an even more robust response to *subsequent* infectious/immune/#inflammatory challenges. And as cells, microglia live long lives (they are not replaced as often as many other cell types)
(1/n) Delighted to share our work using #scRNAseq to explore the intersection between regeneration, development and #immune recognition in #cancer #metastasis online @NatureMedicine @sloan_kettering @WeillCornell @scell_papers @dana_peer @LabMassague
nature.com/articles/s4159…
nature.com/articles/s4159…
@NatureMedicine @sloan_kettering @WeillCornell @scell_papers @dana_peer @LabMassague (2/n) human primary #lungcancer is characterized by the emergence of regenerative cell types, typically seen in response to lung injury, but showing striking lineage promiscuity (identity confused!)
@NatureMedicine @sloan_kettering @WeillCornell @scell_papers @dana_peer @LabMassague (3/n) #metastasis exhibits a continuum of more primitive stem to epithelial progenitor states – driven in large part by key embryonic and lung-specifying transcription factors, SOX2 and SOX9.
#Antisemitic incident!
#Italy #Mailand #Milan
The 89-year-old Milanese Liliena Serge is a #Holocaust #survivor. In January 1944, at the age of 13, she came to #Auschwitz with her father. Unfortunately, her father did not surrive.
#Italy #Mailand #Milan
The 89-year-old Milanese Liliena Serge is a #Holocaust #survivor. In January 1944, at the age of 13, she came to #Auschwitz with her father. Unfortunately, her father did not surrive.
She is now traveling all over #Italy to tell her story, and has even been voted a life #senator in gratitude for her work. But for months, the #Auschwitz survivor Liliana Segre gets Daily Hundreds of hate messages,
death threats and #antiSemitic #inflammatory messages that she is now under permanent #police protection. Yesterday, 5000 Denonstranten met on track 23 in #Milan. (The track for transport to #Auschwitz) At the monument, people met to express their solidarity with the survivors.
And just today this new study further challenges the sterile #placenta! 👉 This team identified R. insidiosa as a bona fide resident at the placental basal plate..by using species-specific FISH probes to confirm + localize R. insidiosa within basal plate tissue specimens at term
1/1 From paper 👉 “We show that R. insidiosa is a bona fide resident in human #placental basal plate. It can access trophoblast cells in culture and within basal plate tissues where it localizes to intracellular single-membrane vacuoles and can replicate...”
2/2 “...However, the presence of R. insidiosa does not cause cell death and does not induce a pro-#inflammatory immune response suggesting that it is not harmful in and of itself...”
This! The activity of the host #immune response largely determines whether #pathobionts acquired from an #FMT donor might become capable of virulence 👉 So including immune status in the study of FMT outcomes would be extremely informative
IMO immune status should be included in the general study of #antibiotic resistant infection 👉 It’s no coincidence that most “superbug” infections occur in immunocompromised patients, often in hospitals (w/ patients on cocktails of steroids for procedures like organ transplants)
Because extrapolate that trend and consider that the immunosuppressive biologics used to palliate “#autoimmune” disease symptoms are the top selling medications in the world 👉 With top side effects of such drugs being “serious #infection by viruses, fungi or bacteria”(see below)
Nice work @drmfreire + team at @JCVenterInst! 👉 They found that local #periodontal pathogen enrichment was positively associated with high systemic inflammatory profiles in patients with Systemic #Lupus Erythematosus: biorxiv.org/content/10.110…
Quote from paper 👉 “...the gut #microbiome, and recently the #oral microbiome, showed direct impact on SLE subjects, the complexity of chronic diseases such as #SLE is beyond isolated body compartments, and it requires the integration of host-microbial interactions.”
Also 👉 “At the center of #autoimmune pathogenesis, this study provides evidence that #inflammatory response to #microbiome controls the severity, and magnitude of the #SLE disease”
“Missing #microbes” are a factor in the development of chronic #inflammatory disease 👉 But personally, I’m more concerned about the fact that many aspects of modern living are driving a rise in “missing #immunity” and the consequent survival of “additional persistent #pathogens”
Here’s an example 👉 #Formula feeding is often associated w/ increased chronic #disease incidence☝️ Meanwhile, #breast milk has a #microbiome, but is ALSO filled w/ antimicrobial compounds + metabolites that play a key role in the immune’s system’s ability to manage #infection
This team found that interactions b/t neonatal #saliva and #breast milk released #antimicrobial compounds including H202☝️These compounds inhibited growth of a range of human pathogens: nature.com/articles/s4159…
Interesting! 👉 But we may never find that holy grail (a common #microbiome dysbiosis tied to specific inflammatory conditions)☝️B/c the microbiome is so vast..that the metabolic dysfunction driven by different #organisms can result in similar clusters of #inflammatory symptoms
Yet we can still use/develop treatments based off “big picture” trends 👉 Eg: no two patients w/ #cancer have the same #tumor mutations☝️But #immununotherapy harnesses the broad potential of activated T cells to target tumors (w/ therapy “details” personalized per #patient)
Plus we’ve already established many common features of #microbiome dysbiosis 👉 KEY being the the ability of #microbes + #viruses to create proteins/metabolites that dysregulate human signaling pathways☝️Good example here: nature.com/articles/s4156…
Why is the future of chronic #inflammatory disease #polymicrobial (organisms interacting)? 👉 This paper describes how even in #Lyme Neuroborreliosis, different strains of Borrelia often persist in a #biofilm, or community-based form: frontiersin.org/articles/10.33…
The ability of Borrelia to form into #biofilm communities may 👉 “explain the low rate of Borrelia detection in the #blood of infected #patients as well as the ability of the #spirochetes to evade the host immune system and resist the antibiotic therapy”: frontiersin.org/articles/10.33…
Here are two images 👉 On the left, a #Borrelia biofilm as seen under a #microscope☝️On the right, a diagram showing how chronic, persister forms of Borrelia can survive inside a #biofilm: where they are better protected from the host immune response: frontiersin.org/articles/10.33…
Here, #measles virus #infection caused lymphocyte depletion, with memory T + B cells being most severely affected☝️This #pathogen-driven immunosupppresion supports survival of “co-morbid” infectious agents (polymicrobial disease) nature.com/articles/s4146…
In fact here, #measles-driven immunosuppression had a prolonged effect on host resistance, extending over 2-3 years science.sciencemag.org/content/348/62… 👉 This suggests measles may promote an atmosphere that favors #microbiome dysbiosis + development of chronic #inflammatory conditions
For more on this trend (pathogen-driven immunosuppression + #microbiome dysbiosis) please read this section of my @JCVI book chapter: 👉 “Early #infections predispose a person to later chronic disease”
