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Ryan McNamara 🧬 Profile picture
@Ryan_Mac_Phd
Oct 27, 2019 • 7 tweets • 4 min read • Read on X
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Sorry, I missed this @Steftyem. But here we go:
#PhotosOfMyLife Day 1 of 7. No people/explanation. Image
Day 2 of 7 #PhotosOfMyLife. No people/explanation Image
Day 3 of 7 #PhotosOfMyLife
No people/explanation Image
Day 4 of 7 #PhotosOfMyLife
No people/explanation Image
Day 5 of 7 #PhotosOfMyLife
No people/explanation Image
Day 6 of 7 #PhotosOfMyLife
No people/explanation Image
And day 7 of 7 #PhotosOfMyLife
No people/explanation ImageImageImage

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More from @Ryan_Mac_Phd

Ryan McNamara 🧬 Profile picture
Jul 25, 2022
Our latest pre-print is up!
In this study, we quantify the functional waning of non-neutralizing (effector) SARS-CoV-2 antibodies across all variants in recipients of two of the most globally administered vaccines: CoronaVac and the mRNA vaccine BNT162b2

biorxiv.org/content/10.110…
We also assess how mRNA vaccine boosters in CoronaVac recipients restore & expand functional responses against variants, particularly Omicron. This is of high global health interest as CoronaVac, an inactivated vaccine, has had billions of doses administered

So what did we find?
Effector functions wane rapidly in CoronaVac recipients, & are beneath our l.o.d. when binding antibodies are still present (~3-4 months for some FcR-binding antibodies). These functional antibodies are not only restored by mRNA vaccines, but functional breadth is expanded.
Read 5 tweets
Ryan McNamara 🧬 Profile picture
Jul 24, 2022
The Sunday evening cookie chronicles I Image
The Sunday evening cookie chronicles II Image
The Sunday evening cookie chronicles III Image
Read 5 tweets
Ryan McNamara 🧬 Profile picture
Nov 16, 2021
The varicella vaccination program began in 1995/6, and the incidence of chickenpox has plummeted >90%.

However, we have yet to "eliminate" varicella after 25 years of intense public health efforts and a highly effective vaccine.
SARS-CoV-2, the causative agent of COVID-19, burst onto the scene in 2019. Like varicella, vaccinations were developed that are highly effective.

However, also like varicella, getting shots into arms is not easy. And reducing incidence when prevalence is high is challenging.
Elimination efforts are extremely difficult. We've only done it a few times, and it took decades of vaccination programs, education, and public health efforts.

Trivializing pathogen elimination and setting unattainable goals can result in loss of trust in public health.
Read 5 tweets
Ryan McNamara 🧬 Profile picture
Oct 7, 2021
This succinct breakdown of the anti-public health messaging of Fox Entertainment by @chrislhayes rings all too familiar.

Throughout last year before the vaccines, I called my family members several times a week to answer any questions or concerns
Most of them were great questions and I tried to help as best I could; but some questions were bonkers.

"Where did you hear that from!?" I would routinely ask, knowing damn well where they heard it from. From chloroquine to "herd immunity by infection", some were just insane
They're just consumers, not field-relevent experts. In fact, more often than not, they would approach the topic like "Hey I heard this and it sounded odd, is it true?" So it's hard to blame them.

This happened endlessly.
Read 4 tweets
Ryan McNamara 🧬 Profile picture
Sep 30, 2021
Some keep stating it's a fact that infection-acquired immunity is superior to vaccine-acquired immunity. That is simply not true.

For one not everyone survives COVID-19. Severe adverse effects from vaccines can occur, but are extremely rare. That already heavily skews the data
Reports show wide variance of immune response to infection acquired immunity in survivors. Some reports show high IgG in severe COVID-19 survivors and low IgG in mild cases.
Vaccines bypass this by eliciting high IgG w/o illness
nature.com/articles/s4146…
academic.oup.com/cid/article/72…
Vaccine-acquired immunity generates similar RBD-neutralizing antibodies that COVID-19 survivors do.
Again, big difference is that they don't have to become sick with COVID-19 to do it. Especially with severe disease.

nature.com/articles/s4158…
Read 5 tweets
Ryan McNamara 🧬 Profile picture
Sep 29, 2021
Weird because a recent CDC MMWR came to the opposite conclusion of this "fact".

In Kentucky unvaccinated individuals were ~2.3x as likely to become re-infected with SARS-CoV-2 than those who were vaccinated.

cdc.gov/mmwr/volumes/7…
There's caveats to this study and other studies have had some other mixed results.

But to present his view as a fact shows that @DrJBhattacharya is more committed to ideology than to objective science and medicine.
It's also complicated by the (ahem) "fact" that Jay is assuming everyone in the room who recovered from COVID is, you know, alive.
Read 4 tweets

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