ISCHEMIA-CKD: Among patients w/ stable ischemic heart disease & stage 4-5 CKD (53% were on dialysis), an initial invasive strategy of cardiac cath. did not lead to a ⬇️ in clinical outcomes vs an initial conservative strategy #AHA19#Nephpearls
👉🏼 professional.heart.org/idc/groups/aha…
ISCHEMIA-CKD: Some caveats 🤔 to consider:
📌 The results do not apply to patients with recent ACS, unacceptable angina despite maximal medical therapy, or significant heart failure because they were excluded #AHA19#Nephpearls
ISCHEMIA-CKD: Among patients with stable coronary disease, advanced CKD, and moderate or severe ischemia, an initial invasive strategy (vs initial conservative strategy), did not reduce the risk of death or nonfatal MI ca. 2020 from @NEJM#Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
ISCHEMIA-CKD: Among patients with stable coronary disease, advanced CKD, and moderate or severe ischemia, an initial invasive strategy (vs initial conservative strategy), did not reduce the risk of death or nonfatal MI ca. 2020 from @NEJM#Nephpearls
👉🏼 nejm.org/doi/full/10.10…
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IgA Nephropathy: The @goKDIGO treatment algorithm recommends consideration of use of corticosteroids in patients with "persistent proteinuria >1g/day" if the risk/benefit profile is favorable
📌 A GFR of 30 is considered a threshold for treatment
Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls
Multiple or metabolically active stones (stones that increase in size/ number w/in a year)
Children
Demographic groups not typically prone to stone formation
Stones other than those containing calcium
Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja#Nephpearls
PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics#NephJC#IPNAJC#Nephpearls
Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph#NephJC#IPNAJC#Nephpearls
PREDNOS: Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome ca. 2019 from @bmj_latest#NephJC#IPNAJC#Nephpearls