Eric Topol Profile picture
Jan 11, 2020 6 tweets 8 min read Read on X
Why the 2019 @BLS_gov Jobs report is a red flag for American #healthcare: bls.gov/news.release/e…
A thread to explain
1. You may recall that in late December 2017, #healthcare jobs overtook retail to become #1 for the first time in US history
@BLS_gov 2. Since that time, the US has added ~1 million more #healthcare jobs, >50,000 more in 2019 than 2018. No sector grew more in 2019.
(NB Education + healthcare sum is ~90% healthcare related)
@BLS_gov 3. Healthcare added the most jobs throughout the past decade
wsj.com/articles/decem… by @EricMorath @TheAmaraReport
@BLS_gov @EricMorath @TheAmaraReport 4. Human capital, i.e. the workforce, is the #1 driver of costs of healthcare. In the US we now pay > $11,000 per person with the worst major outcomes of all 36 @OECD countries. There are no data to suggest that more labor support will improve outcomes.
growthevidence.com/growth-comment…
@BLS_gov @EricMorath @TheAmaraReport @OECD 5. So this is a feed the (broken) beast model. Nothing is being done to address it; the job growth is just celebrated.
Whereas the UK (which has better outcomes at half the cost) undertook an in-depth review & is implementing many worthy strategies
topol.hee.nhs.uk
@BLS_gov @EricMorath @TheAmaraReport @OECD 6. To break up the vicious cycle, costs have to be lowered. Besides getting rid of administrative waste
(> $812,000,000,000 in 2017, annals.org/aim/fullarticl… @AnnalsofIM),
a reduction in the workforce can be accomplished.

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More from @EricTopol

May 16
The connection between #SARSCoV2 and neurodegeneration
@TheLancetNeuro
Quotes below:
1. SARS-CoV-2 infection should be considered as a risk factor for Alzheimer’s disease, even though the distinction between causation versus disease acceleration is not clear.thelancet.com/journals/laneu…Image
2. Inflammation in patients with COVID-19, and controlled experiments show prolonged neuro-inflammation after mild SARS-CoV-2 infection
in macaques.
3. A direct correlation has been reported
between prior SARS-CoV-2 infection and increased risk
of Alzheimer’s disease (figure).

4. So far, the estimated lifetime cumulative risk of dementia due to hospitalisation for any viral infection is 1·48 (95% CI 1·15–1·91).
Read 5 tweets
Apr 26
The FLiRT variant KP.2 begins its takeover for Covid cases in the US, now accounting for 1 in 4 cases
covid.cdc.gov/covid-data-tra…
Image
I've reviewed the FLiRT variants and their implications in a Ground Truths (link in profile) Image
The 2 mutations in the spike that account for KP.2's rise to dominance, compared with the JN.1 variant which has prevailed for months Image
Read 5 tweets
Jan 22
Breaking down the risks and benefit for lecanemab, the amyloid beta-directed antibody vs Alzheimer's drug approved @US_FDA last year. It doesn't look good.

@AnnalsofIM acpjournals.org/doi/10.7326/M2…
Image
A new systematic review of these antibodies looks even worse @AnnFamMed doi.org/10.1370/afm.30…



Image
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Fixed link for this important paper
annfammed.org/content/22/1/5…
Read 4 tweets
Jan 4
My oped on the JN.1 variant and the 2nd biggest US wave of infections (after Omicron) since the pandemic began
@latimes @latimesopinion #LongCovid latimes.com/opinion/story/…
Image
Recent @CDCgov #SARSCoV2 wastewater data for current wave (vs Omicron Jan 2022 and subsequent waves), graph by @luckytran Image
Sorry, @washingtonpost, but this is not "another Covid-19 uptick" as you put it in your Health Alert. You ignore the best metric for infections that we have at present—wastewater—focusing only on hospitalizations
washingtonpost.com/health/2024/01…
Image
Read 4 tweets
Nov 23, 2023
3 New #LongCovid reports
1. Vaccination protection—1 dose 21%, 2 doses 59%, 3 doses 73% among ~590,000 people in Sweden (strong association)
bmj.com/content/383/bm…
Image
2. 3-year prospective follow up of a cohort of ~1350 participants, hospitalized in China
—Lung function restored back to baseline in most
—Higher risk of reinfection that people w/o Long Covid
—Half w/ persistent symptoms
thelancet.com/journals/lanre…
3. At @RSNA annual meeting, brain MRI with microstructure imaging (DMI), participants with #LongCovid vs controls had microstructure changes associated with impaired cognition, sense of smell and fatigue
eurekalert.org/news-releases/…
Image
Read 6 tweets
Aug 25, 2023
Big news #ESC2023 and @NEJM
In a placebo-controlled randomized trial of people with obesity + heart failure (with preserved ejection fraction). semaglutide (Wegovy) markedly improved symptoms, exercise time, reduced inflammatory markers (and weight loss)
nejm.org/doi/full/10.10…

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This also tells us something about the underlying mechanism of heart failure with preserved EF—metabolic dysfunction and attendant systemic inflammation—not previously acknowledged or confirmed
The accompanying editorial lays this finding out well. Prior studies of weight loss didn't help HFpEF
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Read 4 tweets

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