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Edgar V. Lerma 🇵🇭 Profile picture
@edgarvlermamd
Jan 29, 2020 • 10 tweets • 13 min read • Read on X
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Risk of Nephrogenic Systemic Fibrosis in Patients With Stage 4 or 5 Chronic Kidney Disease Receiving a Group II Gadolinium-Based Contrast Agent: A Systematic Review and Meta-analysis ca. 2019
#VisualAbstract by @VickiSandys1
#NephJC #Nephpearls
👉🏼 jamanetwork.com/journals/jamai… ImageImage
Chart showing cumulative Nephrogenic Systemic Fibrosis (NSF) cases reported to the NSF Registry by date of onset through 2012
📌 Important FDA announcements are marked on the timeline
#Nephpearls #NephJC ImageImage
Depiction of the current gadolinium-based contrast agents approved for clinical use in Canada 🇨🇦 #Nephpearls #NephJC
👉🏼 ncbi.nlm.nih.gov/pmc/articles/P… ImageImage
Which is WORSE ⁉️ Risk of Gadolinium Nephrotoxicity or Radiocontrast Nephropathy #Nephpearls #NephJC #AskRenal ImageImage
On GADOLINIUM and the Kidney
1⃣ Nephrogenic Systemic Fibrosis
2⃣ AKI
3⃣ Pseudohypocalcemia
#Nephpearls #NephJC
👉🏼 ncbi.nlm.nih.gov/m/pubmed/18033… Image
In this illustration, a nonionic linear chelate (gadodiamide), which binds Gd3􏰁 less tightly than other chelates (macrocyclic and ionic), is shown undergoing the process of transmetallation #Nephpearls #NephJC
👉🏼 cjasn.asnjournals.org/content/clinja… ImageImage
Nephrogenic Systemic Fibrosis: Differential Diagnosis #Nephpearls #NephJC
👉🏼 mdedge.com/ccjm/article/9… ImageImage
Nephrogenic Systemic Fibrosis: Prevention and Treatment from @NephRodby’s lecture
#NKFClinicals 2019 #Nephpearls #NephJC
👉🏼 ncbi.nlm.nih.gov/m/pubmed/17555… ImageImageImageImage
Although Nephrogenic Systemic Fibrosis occurrence after exposure to newer GBCAs is very rare, the relatively scarce data among patients w/ AKI and those w/ risk factors for CKD limit conclusions about safety‼️ (ca. 2020) from @AnnalsofIM #Nephpearls
👉🏼 acpjournals.org/doi/pdf/10.732… ImageImageImage
Risks and Options With Gadolinium-Based Contrast Agents in Patients With CKD: A Review ca. 2020 from @AJKDonline @MichaelRudnick7 #Nephpearls
👉🏼 ajkd.org/action/showPdf… ImageImageImageImage

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More from @edgarvlermamd

Edgar V. Lerma 🇵🇭 Profile picture
Feb 26, 2022
Advancing Evidence-Based Care in Diabetes and CKD
#ISNWCN 🇲🇾 #Nephpearls

👉 kdigo.org/wp-content/upl…
Holistic approach for improving outcomes in patients with Diabetes and CKD
#ISNWCN 🇲🇾 #Nephpearls
Glucose-lowering agents in Type 2 Diabetes (T2D) and CKD: Indications and dose adjustments
#ISNWCN 🇲🇾 #Nephpearls
Read 9 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Feb 26, 2022
.@goKDIGO Glomerular Diseases Guideline: Reflections on a Decade of Progress with @adrianliew8 @ReichHeather @Dr_KeishaGibson
#ISNWCN 🇲🇾 #Nephpearls

👉 kdigo.org/wp-content/upl…
IgA Nephropathy: A 1st step is in treating IgA Nephropathy is assessing "prognosis" based on data available at the time of biopsy

@goKDIGO suggest using the "prediction tool" that was derived from the largest & most geographically diverse cohort to date

#ISNWCN 🇲🇾 #Nephpearls
IgA Nephropathy: The @goKDIGO treatment algorithm recommends consideration of use of corticosteroids in patients with "persistent proteinuria >1g/day" if the risk/benefit profile is favorable

📌 A GFR of 30 is considered a threshold for treatment

#ISNWCN 🇲🇾 #Nephpearls
Read 13 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Feb 23, 2022
First clinical-grade porcine 🐖 kidney xenotransplant using a human decedent model ca. 2022 from @amjtransplant #NephJC #Nephpearls

#VisualAbstract by @NamrataYParikh

👉🏼 pubmed.ncbi.nlm.nih.gov/35049121/ Image
Attitudes to Clinical Pig Kidney Xenotransplantation among Medical Providers and Patients ca. 2020 from @ASNKidney360 #Nephpearls

kidney360.asnjournals.org/content/1/7/657 ImageImage
Paving the Path toward Porcine Organs for Transplantation ca. 2017 from @NEJM #NephJC #Nephpearls

nejm.org/doi/full/10.10… ImageImage
Read 4 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Jan 30, 2022
Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls

Multiple or metabolically active stones (stones that increase in size/ number w/in a year)

Children

Demographic groups not typically prone to stone formation

Stones other than those containing calcium ImageImage
Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja #Nephpearls

sciencedirect.com/science/articl… Image
Neglected analytes in the 24 hour urine: ammonium and sulfate ca. 2021 from @CO_Neph_Hype @ravineja #Nephpearls

👉 pubmed.ncbi.nlm.nih.gov/34798636/ ImageImageImageImage
Read 4 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Jan 26, 2022
PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @drM_sudha

jamanetwork.com/journals/jamap…
Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @md_abdulqader83

link.springer.com/article/10.100…
PREDNOS: Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome ca. 2019 from @bmj_latest #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @jbda19

pubmed.ncbi.nlm.nih.gov/31156083/
Read 5 tweets
Edgar V. Lerma 🇵🇭 Profile picture
Nov 17, 2021
Clinical Practice Guideline for the Management of Glomerular Diseases ca. 2021 from @goKDIGO #NephJC #Nephpearls
#VisualGraphics by @michaelturk6

Executive Summary pubmed.ncbi.nlm.nih.gov/34556300/
Full Guideline pubmed.ncbi.nlm.nih.gov/34556256/
The spectrum of glomerular diseases from @neilturn #NephJC #Nephpearls

👉 global.oup.com/academic/produ…
Nephrotic range proteinuria does "not always" mean nephrotic syndrome #NephJC #Nephpearls

👉 pubmed.ncbi.nlm.nih.gov/34556256/
Read 4 tweets

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