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Natasha Loder Profile picture
@natashaloder
Feb 5, 2020 • 3 tweets • 2 min read • Read on X
So next week there will be a Global Research and Innovation Forum hosted by WHO which will get into trials for therapeutics for #2019_nCov #WuhanVirus. My understanding from speaking to @WHO last night was that the HIV combination was seen as “promising”. But...
There are many options. The Chinese have a list of 30 products they are interested in—-including TCM. So one topic of discussion will be the prioritisation of drug trials. Ie which ones look most promising. There is one other thing. I anticipate two kinds of trial...
One will be compassionate use of drugs for critically ill patients. The other will be RCTs with placebo arms for hospitalised patients. As most of the patients are currently in China I expect most of these trials will start there. #nCoV19

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More from @natashaloder

Natasha Loder Profile picture
Sep 20, 2023
🚨 Can common infections cause psychiatric conditions in children? Yes.

A UK health minister Maria Caulfield told parliament on September 12th that the childhood condition PANDAS/PANS exists and is caused by infections. It will fund more research.🧵
Lack of recognition of PANDAS/PANS is a problem internationaly.

A new piece by me describes the growing consensus that the condition seems to be driven by an autoimmune reaction that targets regions of the brain
@DrChrisPitt @DAgalliu @More4Scienceeconomist.com/science-and-te…
Children that are healthy and developmentally on track suddenly start exhibiting OCD or other neuropsychiatric symptoms such as tics, anxiety, irritability and anger. It comes on quickly.
Read 8 tweets
Natasha Loder Profile picture
Mar 19, 2023
So one of the new narratives emerging is that @MichaelWorobey went on a media blitz to promote their version of events—in order to bolster the case for a zoonosis in Wuhan.

I suspect this is inaccurate.

For one thing *prior* to this story breaking in the Atlantic, Worobey… twitter.com/i/web/status/1…
In other words it seems likely the team had hoped and planned to keep a media silence around this discussion of the new data—because it wasn’t theirs.

But as the group of people who knew about that meeting grew, it would have likely proven difficult to keep a lid on the story.
Let’s not fill the lack of information about the precise series of events with devious motives and narratives. I think much more will become clear when the Nature paper is published. And Worobey et al publish their report with their conclusions.

On that topic of devious… twitter.com/i/web/status/1…
Read 6 tweets
Natasha Loder Profile picture
Mar 17, 2023
So @who weekly presser started and @tedros talking. Says data was uploaded in late January. Data not definitive answer to how pandemic began
@WHO @tedros This data should have been shared three years ago says @tedros. Calls on China to be transparent. Understanding how covid began moral and scientific imperative
The SAGO scientific advisory group at @who met last Tuesday says @DrTedros
Read 21 tweets
Natasha Loder Profile picture
Jan 31, 2023
Help needed. Poll at the end. 🧵

Should we say "obese people"?

One researcher tells me not to do this because we don't say "cancer people" and it is stigmatising.

One of our style gurus (SG) counters: "obese is an adjective, cancer is a noun".
So one might write "obese mothers have a higher risk of gestational diabetes".

I go back to the researcher and he counters back:

"cancerous is also an adjective. But you would never use it to describe someone with cancer".

Researcher adds,
.. in diabetes the use of "diabetics" is being phased out 🤯.

.. and the same discussion on obesity is ongoing.

Then he says I will be "on the wrong side of history" writing something like "obese people" rather than "people with obesity"
Read 9 tweets
Natasha Loder Profile picture
Dec 16, 2021
Couple of interesting @Airfinity slides at the @IFPMA briefing earlier.

First one shows that if 50% of production is shifted to make a variant vaccine that there will be a three billion dose shortfall by the middle of 2022.

Why?
The reason is the overheads that accrue with switching from one vaccine to another on a production line. (Stop the line, clean it, restart it, get it inspected, and so on).

This is the first quantification I have seen of the hidden costs of moving to variant vaccines.
It is true we can design and make a novel variant vaccine in under 100 days. But making it at scale is a different challenge.

Of course, it can be done. But if you are going to do it, you have to make sure that the cost of switching (fewer doses) are worthwhile.
Read 7 tweets
Natasha Loder Profile picture
Dec 14, 2021
"At this point we believe there is hope that the severity is lower" #Omicron
Image
Slides coming now from Discovery Health and their real-world study of Pfizer vaccine efficacy. Image
Read 15 tweets

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