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Edgar V. Lerma 🇵🇭

@edgarvlermamd

Feb 26, 2020 • 11 tweets • 12 min read • Read on X

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@NephroGuy

PEXIVAS: In severe ANCA vasculitis, PLEX did not reduce the incidence of death/ ESKD

📌 A ⬇️ dose regimen of glucocorticoids was noninferior to a standard-dose regimen w/ respect to death/ ESKD

#VisualAbstract by @NephroGuy
#NephJC #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…

Therapeutic Apheresis 101
📌 Extracorporeal procedures whereby blood separation technology is used to remove abnormal blood cells and/or plasma constituents
🔲 Plasmamapheresis
🔲 Leukapheresis
🔲 Erythrocytapheresis
🔲 Thrombocytapheresis
#Nephpearls #NephJC

In plasmapheresis, or therapeutic plasma exchange (TPE), large quantities of plasma are removed from a patient and replaced with
👉🏼 Fresh frozen plasma (FFP), or
👉🏼 Albumin solutions in normal saline
#Nephpearls #NephJC

Indications for Urgent Plasmapheresis and Cytapheresis
#Nephpearls #NephJC

Complications of Plasmapheresis #Nephpearls #NephJC

Strategies to avoid complications during Plasmapheresis
#Nephpearls #NephJC

@JASN_News

Randomized Trial of Plasma Exchange or High-Dosage Methylprednisolone as Adjunctive Therapy for Severe Renal Vasculitis (MEPEX) ca. 2007 from @JASN_News
#VisualAbstract by @madmagicdoc
#Nephpearls #NephJC
👉🏼 jasn.asnjournals.org/content/jnephr…

@BioMedCentral

The role of plasma exchange in treating post-transplant FSGS ca. 2016 from @BioMedCentral
#Nephpearls #NephJC
👉🏼 ncbi.nlm.nih.gov/pmc/articles/P…

@CJASN

Principles of Separation: Indications and Therapeutic Targets for Plasma Exchange ca. 2014 from @CJASN
#Nephpearls #NephJC
👉🏼 cjasn.asnjournals.org/content/clinja…

@HerrmannMd

MT @HerrmannMd SPECKS: Updates in ANCA Vasculitis
🔬 ANCA-type matters
💉 Less (no) cyclophosphamide
🩸 No Plasma Exchange‼️
💊 Less (no) glucocorticoids
#MayoUpdate2020 #Nephpearls

@NatRevNeph

Key Findings in PEXIVAS ca. 2020 from @NatRevNeph #Nephpearls
nature.com/articles/s4158…

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More from @edgarvlermamd

Edgar V. Lerma 🇵🇭

@edgarvlermamd

Feb 26, 2022

Advancing Evidence-Based Care in Diabetes and CKD
#ISNWCN 🇲🇾 #Nephpearls

👉 kdigo.org/wp-content/upl…

Holistic approach for improving outcomes in patients with Diabetes and CKD
#ISNWCN 🇲🇾 #Nephpearls

Glucose-lowering agents in Type 2 Diabetes (T2D) and CKD: Indications and dose adjustments
#ISNWCN 🇲🇾 #Nephpearls

Read 9 tweets

Edgar V. Lerma 🇵🇭

@edgarvlermamd

Feb 26, 2022

@goKDIGO

.@goKDIGO Glomerular Diseases Guideline: Reflections on a Decade of Progress with @adrianliew8 @ReichHeather @Dr_KeishaGibson
#ISNWCN 🇲🇾 #Nephpearls

👉 kdigo.org/wp-content/upl…

@goKDIGO

IgA Nephropathy: A 1st step is in treating IgA Nephropathy is assessing "prognosis" based on data available at the time of biopsy

@goKDIGO suggest using the "prediction tool" that was derived from the largest & most geographically diverse cohort to date

#ISNWCN 🇲🇾 #Nephpearls

@goKDIGO

IgA Nephropathy: The @goKDIGO treatment algorithm recommends consideration of use of corticosteroids in patients with "persistent proteinuria >1g/day" if the risk/benefit profile is favorable

📌 A GFR of 30 is considered a threshold for treatment

#ISNWCN 🇲🇾 #Nephpearls

Read 13 tweets

Edgar V. Lerma 🇵🇭

@edgarvlermamd

Feb 23, 2022

@amjtransplant

First clinical-grade porcine 🐖 kidney xenotransplant using a human decedent model ca. 2022 from @amjtransplant #NephJC #Nephpearls

#VisualAbstract by @NamrataYParikh

👉🏼 pubmed.ncbi.nlm.nih.gov/35049121/

@ASNKidney360

Attitudes to Clinical Pig Kidney Xenotransplantation among Medical Providers and Patients ca. 2020 from @ASNKidney360 #Nephpearls

kidney360.asnjournals.org/content/1/7/657

@NEJM

Paving the Path toward Porcine Organs for Transplantation ca. 2017 from @NEJM #NephJC #Nephpearls

nejm.org/doi/full/10.10…

Read 4 tweets

Edgar V. Lerma 🇵🇭

@edgarvlermamd

Jan 30, 2022

Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls

Multiple or metabolically active stones (stones that increase in size/ number w/in a year)

Children

Demographic groups not typically prone to stone formation

Stones other than those containing calcium

@ravineja

Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja #Nephpearls

sciencedirect.com/science/articl…

@CO_Neph_Hype

Neglected analytes in the 24 hour urine: ammonium and sulfate ca. 2021 from @CO_Neph_Hype @ravineja #Nephpearls

👉 pubmed.ncbi.nlm.nih.gov/34798636/

Read 4 tweets

Edgar V. Lerma 🇵🇭

@edgarvlermamd

Jan 26, 2022

@JAMAPediatrics

PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @drM_sudha

jamanetwork.com/journals/jamap…

@Ped_Neph

Low-dose versus conventional-dose prednisolone for nephrotic syndrome relapses: a randomized controlled non-inferiority trial ca. 2022 from @Ped_Neph #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @md_abdulqader83

link.springer.com/article/10.100…

@bmj_latest

PREDNOS: Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome ca. 2019 from @bmj_latest #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @jbda19

pubmed.ncbi.nlm.nih.gov/31156083/

Read 5 tweets

Edgar V. Lerma 🇵🇭

@edgarvlermamd

Nov 17, 2021

@goKDIGO

Clinical Practice Guideline for the Management of Glomerular Diseases ca. 2021 from @goKDIGO #NephJC #Nephpearls
#VisualGraphics by @michaelturk6

Executive Summary pubmed.ncbi.nlm.nih.gov/34556300/
Full Guideline pubmed.ncbi.nlm.nih.gov/34556256/

@neilturn

The spectrum of glomerular diseases from @neilturn #NephJC #Nephpearls

👉 global.oup.com/academic/produ…

Nephrotic range proteinuria does "not always" mean nephrotic syndrome #NephJC #Nephpearls

👉 pubmed.ncbi.nlm.nih.gov/34556256/

Read 4 tweets

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