🚨Alot of🗣about COVID-19🚨
Great commentary by @OncLive about⤴️risk in pts with cancer or immunodef.
⚠️Nationwide🌏analysis of 1590 pts w/laboratory-conf COVID-19
Pts w/cancer➡️⤴️ risk ICU admission requiring invasive ventilation,or death (39% vs 18% P = 0003)
👇🏻
Pts w/cancer “deteriorated more rapidly” ⛔️(HR, 3.56; 95% CI, 1.65-7.69; P < .0001)⛔️
Pts w. chemo or surgery with 𝟭 month📆⤴️ risk of severe events(75% vs 43%)
Even if a vaccine is made, pts w/immunodef do not produce enough antibodies 4 protection🤯
So what do we do🧐
✅Encourage 🙌🏻 hygiene
✅Cover 🤧 and sneezes
✅Stay HOME 🏡 if not feeling well 🤒
✅Remain vigilant about monitoring for infection (may not mount same signs of symptoms due to low WBC!)
Last week I had one of my final presentations of the year! With a catchy title😉
Urine for an Update! Updates in the management of metastatic urothelial cancer
Hold your bladders, this is an extensive update! 😂 #oncopharm
Bladder cancer can be divided into two ✌️subtypes: 1) Non-muscle invasive: encompasses in-situ and localized disease➡️5-yr OS >70%
2) Muscle invasive: encompasses regional or metastatic disease➡️5-yr OS dismal especially for metastatic disease 😔
Cisplatin=SOC
50% of pts w are ineligible due to older age👵🏻, poor PS, ⬇️ renal function, ⬇️hearing, neuropathy, heart failure 🫀& other comorbities that ⬆️ risk of ⚠️
Carboplatin yields inferior responses➡️NOT 🙅🏻♀️ an equal alternative due to ⬇️ OS😢➡️pt left w/minimal tx options
What medications 💊 are should be avoided 🛑 or used with caution ⚠️ in patients with Myasthenia Gravis? 🤔
See 👀 the thread 🧵below⤵️ that summarizes an amazing grand rounds presentation by @UKPharmRes PGY1 @AliW_PharmD on key 🔑 medication considerations in MG
1️⃣Antibiotics to avoid or use w/caution🦠 💊
🛑FQs = FDA BBW for ⤴️ risk of MG crisis ➡️ avoid use if possible
⚠️ Macrolides ⤴️ rate of MG crisis (case reports)
⚠️ AG linked to ⤴️ ICU acquired weakness & exacerbate ‼️ MG crisis
📝Risk⬆️ w/neomycin vs. tobramycin & amikacin
Antibiotics considered to be SAFE alternatives to the above include
✅Beta-lactams
✅Tetracyclines
✅Linezolid
✅Bactrim
Ex. In an MG patient who presents 🏥 w/CAP 🫁 ➡️ choose ceftriaxone + doxycycline✅ OVER ceftriaxone + azithromycin🛑