Thread by @KizzyPhD

Look👀More phase 1 trial news:
"Moderna's COVID-19 vaccine trial starts enrolling high-dose arm"

Pretty smooth how we announce the high-dose arm of the phase 1 is enrolling & Moderna sprinkles a data teaser...

fiercebiotech.com/biotech/modern…

...from their Zika vaccine candidate.

Bags 💰Secured >>> Moderna Announces Award from U.S. Government Agency BARDA for up to $483 Million to Accelerate Development of mRNA Vaccine (mRNA-1273) Against Novel Coronavirus
businesswire.com/news/home/2020…

Happy Monday Tweetologists....Here is a little of our vaccine clinical trial data teaser for ya.
📊💙🦠💚

🗣️Moderna Announces Positive Interim Phase 1 Data for its mRNA Vaccine (mRNA-1273) Against Novel Coronavirus
bit.ly/3g9Rzi2

*exhales...* 😃

Moderna advances late-stage development of its vaccine (mRNA-1273) against COVID-19 businesswire.com/news/home/2020…

Our COVID vaccine's (mRNA-1273) immunogenicity in mice is live. As a bonus, we sprinkled in MERS mRNA vaccine efforts that started b4 SARS2 was a thing.
💚🦠💉❤️
SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness (pre-print)
biorxiv.org/content/10.110…

A large collaborative effort, yrs in the making towards prototype pathogen vaccine design & platform delivery between us, @Baric_Lab, @DenisonLab, @McLellan_Lab ... & of course @moderna_tx. (& more)

https://twitter.com/KizzyPhD/status/1230390260841971712?s=20

The phase 1 preliminary report is out!!! ENJOY THE READ!!! (and the AMAZING immune responses 🙃😊)

"An mRNA Vaccine against SARS-CoV-2 — Preliminary Report"
nejm.org/doi/full/10.10…

Wanna see some new data?

RIGHT NOW: Moderna is presenting our newest data from Phase 1. Tune in 💚🙃🦠 ustream.tv/channel/VWBXKB…

Safety and Immunogenicity of mRNA-1273 in Older Adults. The paper is out!!!
nejm.org/doi/full/10.10…

Moderna Completes Enrollment of Phase 3 COVE Study of mRNA Vaccine Against COVID-19 (mRNA-1273)

Salute to the REAL MVPs (30,000+ people) who gave their time and trust to the science of it all. You are more than data points... You are a heroes!!! 🦠💚

apnews.com/press-release/…

94.1%.

100% efficacy against severe COVID for a lil’ razzle dazzle.

https://twitter.com/moderna_tx/status/1333381353488994310

And, the age de-escalation begins...

https://twitter.com/moderna_tx/status/1337005256132190211

Hopefully, you all will be tuning into the FDA Vaccines and Related Biological Products Advisory Committee Meeting on December 17, 2020 to hear all about the Moderna COVID-19 Vaccine.

In preparation, here is the briefing document full of data: fda.gov/media/144434/d…

https://twitter.com/moderna_tx/status/1339702323443077134

The juxtaposition of the EUA announcement in a text with my boss #drbarney with the MERS coronavirus stabilized spike protein bound to antibodies as his phone background is HISTORIC!

“Whoop whoop”!

History reference: instagram.com/p/CBh_gNZjGkv/…

mRNA-1273 PEER-REVIEWED PHASE 3 DATA

*anticlimax drumroll* if you read the FDA EUA package...

“94.1% efficacy at preventing Covid-19 illness, including severe disease. Aside from transient local & systemic reactions, no safety concerns were identified” nejm.org/doi/10.1056/NE…

Good morning esp. to @moderna_tx scientists who woke up a year ago to begin manufacturing clinical-grade mRNA-1273. The beauty of their platform and manufacturing expertise is that it only took 41 days to ship pure "ready-for-muscle" vaccine product. 💉❤️nature.com/articles/s4158…