KizzyPhD Profile picture
14 Apr 20, 17 tweets, 8 min read
Look👀More phase 1 trial news:
"Moderna's COVID-19 vaccine trial starts enrolling high-dose arm"

Pretty smooth how we announce the high-dose arm of the phase 1 is enrolling & Moderna sprinkles a data teaser...

fiercebiotech.com/biotech/modern…

...from their Zika vaccine candidate.
Bags 💰Secured >>> Moderna Announces Award from U.S. Government Agency BARDA for up to $483 Million to Accelerate Development of mRNA Vaccine (mRNA-1273) Against Novel Coronavirus
businesswire.com/news/home/2020…
Happy Monday Tweetologists....Here is a little of our vaccine clinical trial data teaser for ya.
📊💙🦠💚

🗣️Moderna Announces Positive Interim Phase 1 Data for its mRNA Vaccine (mRNA-1273) Against Novel Coronavirus
bit.ly/3g9Rzi2

*exhales...* 😃
Moderna advances late-stage development of its vaccine (mRNA-1273) against COVID-19 businesswire.com/news/home/2020…
Our COVID vaccine's (mRNA-1273) immunogenicity in mice is live. As a bonus, we sprinkled in MERS mRNA vaccine efforts that started b4 SARS2 was a thing.
💚🦠💉❤️
SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness (pre-print)
biorxiv.org/content/10.110…
A large collaborative effort, yrs in the making towards prototype pathogen vaccine design & platform delivery between us, @Baric_Lab, @DenisonLab, @McLellan_Lab ... & of course @moderna_tx. (& more)

The phase 1 preliminary report is out!!! ENJOY THE READ!!! (and the AMAZING immune responses 🙃😊)

"An mRNA Vaccine against SARS-CoV-2 — Preliminary Report"
nejm.org/doi/full/10.10…
Wanna see some new data?

RIGHT NOW: Moderna is presenting our newest data from Phase 1. Tune in 💚🙃🦠 ustream.tv/channel/VWBXKB… Image
Safety and Immunogenicity of mRNA-1273 in Older Adults. The paper is out!!!
nejm.org/doi/full/10.10…
Moderna Completes Enrollment of Phase 3 COVE Study of mRNA Vaccine Against COVID-19 (mRNA-1273)

Salute to the REAL MVPs (30,000+ people) who gave their time and trust to the science of it all. You are more than data points... You are a heroes!!! 🦠💚

apnews.com/press-release/…
94.1%.

100% efficacy against severe COVID for a lil’ razzle dazzle.
And, the age de-escalation begins...
Hopefully, you all will be tuning into the FDA Vaccines and Related Biological Products Advisory Committee Meeting on December 17, 2020 to hear all about the Moderna COVID-19 Vaccine.

In preparation, here is the briefing document full of data: fda.gov/media/144434/d…
The juxtaposition of the EUA announcement in a text with my boss #drbarney with the MERS coronavirus stabilized spike protein bound to antibodies as his phone background is HISTORIC!

“Whoop whoop”!

History reference: instagram.com/p/CBh_gNZjGkv/… Image
mRNA-1273 PEER-REVIEWED PHASE 3 DATA

*anticlimax drumroll* if you read the FDA EUA package...

“94.1% efficacy at preventing Covid-19 illness, including severe disease. Aside from transient local & systemic reactions, no safety concerns were identified” nejm.org/doi/10.1056/NE…
Good morning esp. to @moderna_tx scientists who woke up a year ago to begin manufacturing clinical-grade mRNA-1273. The beauty of their platform and manufacturing expertise is that it only took 41 days to ship pure "ready-for-muscle" vaccine product. 💉❤️nature.com/articles/s4158… Image

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with KizzyPhD

KizzyPhD Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @KizzyPhD

12 Jan
Yes, we will! But, we really all have to do it together!!!

Masking.
Staying still.
Social responsibility.

... vaccination.
And, I put vaccination there because a lot of ppl use the “I’ll just wait for herd immunity argument” to justify their right/choice to not get vaccinated. Here is a thread of why that is a flawed argument.
1. There are people who may not be able to be vaccinated yet. (Immunocompromised, children, etc.) thus refusing your dose means one less able person to build that critical population immunity. Vaccination IS community service.
Read 6 tweets
21 Dec 20
Live view of our neutralization assay team scrambling to make yet another virus variant every time the media publishes about a new single amino acid change without context. 😒
Here is the context: you are going to read and hear about a million and one variant viruses, because viruses mutate by nature. It’s scary, I know. But, a couple of amino acids is not the same a whole whole new virus strain in the way that we’ve been taught to think about flu.
What is happening, often times, is selective pressure. As the virus transmits it learns how to be better at transmitting. This is why you hear “circulating faster than last variant”...
Read 8 tweets
16 Dec 20
Live view of me watching tv specials about the vaccine, and thinking it’s great there are infographics, but then seeing that the mRNA-expressed spike proteins aren’t transmembrane-anchored.
Ok, my lay followers are gathering me up in the comments like “huh?” I was purposely making a corny science joke, but folks are here to learn. So...
The spike protein is a surface molecule on the virus so the point of vaccination is to teach your immune system how to recognize it. So if you come in contact with the virus later your body is quick to fight off the virus.
Read 5 tweets
18 Nov 20
I'm RT'ing this to start a thread of my personal appearances and community outreach.

*so bookmark the thread if interested*
Stop # 1: Tonight, @blackdoctor (blackdoctor.org) is hosting me, @JamesEKHildreth, and several other experts on a panel to help ease uncertainty around recent trial results and tell you exactly what they mean.

Stop #2: Tomorrow (11/19), I will join The National Medical Association on a COVID-19 Town Hall. It will be on Facebook Live. *Register Below*
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!