@wellcometrust @JonathanHeeney @JeremyFarrar @RidgeOnSunday @SophyRidgeSky Absolutely spot on and crystal clear as always, and in under 1 min, Jeremy! 😎🤩😍
@wellcometrust @JonathanHeeney @JeremyFarrar @RidgeOnSunday @SophyRidgeSky Yey, while I agree that vaccine discovery, development, production and distribution have indeed progressed considerably in the last decade, I think it is fair to say there is still no such thing as rational vaccine design. It seems you agree since you explained that even for...
@wellcometrust @JonathanHeeney @JeremyFarrar @RidgeOnSunday @SophyRidgeSky a relatively simple, compact and not quickly antigenically changing virus such as COV19, we can not be sure to obtain a protective antigenic preparation in the near future. Even now, when we so desperately need it and litterally every lab with any expertise to this area has...
@wellcometrust @JonathanHeeney @JeremyFarrar @RidgeOnSunday @SophyRidgeSky poured every waking hour into this quest. So, please, please can we agree that, when this is hopefully all over, and positively concluded, we will give serious thought, systematic attention and substantial means to understanding the correlates of protection for every known kind..
@wellcometrust @JonathanHeeney @JeremyFarrar @RidgeOnSunday @SophyRidgeSky of human pathogen for which we do not yet have a working vaccine paradigm? I believe the tools to systemically understand B cell and T cell responses in individual humans have been available for at least a decade as well. And yet, for not human pathogen, not even the hideous No.1
@wellcometrust @JonathanHeeney @JeremyFarrar @RidgeOnSunday @SophyRidgeSky , Mtb, do we fully understand the immunological correlates of protection, disease containment or reactivation. And so, as you know, and as is happening now for COV19, for each pathogen we need to try n number of approaches, or rather effectively "shots in the dark" in the hope
@wellcometrust @JonathanHeeney @JeremyFarrar @RidgeOnSunday @SophyRidgeSky of, sooner rather than later, stumbling on an effective one. Surely we intelligent beings can do better than that in this day and age?
@wellcometrust @JonathanHeeney @JeremyFarrar @RidgeOnSunday @SophyRidgeSky Finally, I will add one last thought if I may... I think the way manufacture vaccines, to sum up basically cooking up one antigenic (ie, protein) preparation or another, is going to turn out to be very, very difficult indeed to scale up to the billions of doses we will need to
@wellcometrust @JonathanHeeney @JeremyFarrar @RidgeOnSunday @SophyRidgeSky overcome COV19, or even to control its spread in the next 12-18 m. So, as I am sure you already have foreseen, we will need to give particularly strong support now to those developing vaccines based on quickly synthesised, standardised, replicable & replicating nucleic acids.
Hello @jay_salsa, how are you and yours? We're very well here in Lyon. Thanks for reading my scientific prose...😇😘😉
