1/ #MRPearls Epistaxis is a common complaint seen in both the inpatient and outpatient settings with approximately 60% of the general population having an episode of epistaxis in their lifetime with a pretty clear bimodal distribution (<10yo and >50yo). #Tweetorial@VCU_IMRes
3/ #MRPearls The etiology of most epistaxis cases can be readily identified through a focused history and physical exam. Important to ask about prior bleeding episodes, medications, OTCs including herbals, and other co-morbidities. @nehahipp@LauraLee714@ETKirtonDavis
5/ #MRPearls Initial management of epistaxis should include evaluation of the airway and assessing for hemodynamic stability. Additionally, you should start with basic tamponade maneuvers.
6/ #MRPearls These tamponade maneuvers require the patient to grasp the nasal alae distally and pinch them tightly continuously for at least 10 minutes before reassessing. Patient should also lean forward to prevent aspiration.
7/ #MRPearls If bleeding persists, then can consider cautery with silver nitrate. Nasal packing in the anterior nares should be considered if bleeding persists following cautery. And finally if nasal packing fails, then can consider nasal tampon.
8/ #MRPearls The use of antibiotics in patients with nasal packing is very highly controversial; however, most likely not needed for anterior packing. Should consult your ENT colleagues if requiring nasal tampon considering patient is at risk for toxic shock syndrome. @bqueenhoo
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2/CF results from a pathogenic mutation on a single gene located on chromosome 7 that encodes the cystic fibrosis transmembrane conductance regulator protein (CFTR). The CFTR serves as a regulated chloride channel that is important in the viscosity of secretions. @mdlizs
3/The CFTR2 database currently reports over 2k different mutations of the CFTR gene; however, the phenotypic expression of these mutations varies based on the functionality of the gene. The most common mutation is the F508del mutation, which is found in ~ 90% of CF patients.
2/Sweat chloride testing can help confirm the diagnosis; however, in individuals with intermediate results (30-59 mmol/L) further testing needs to be completed. These charts from @CF_Foundation highlights sweat chloride testing results.
3/However, sweat chloride testing can result in false positives for a multitude of different reasons. Here a few common causes:
1⃣Adrenal Insufficiency
2⃣Hypothyroidism
3⃣Panhypopituitarism
4⃣Pancreatitis
5⃣Malnutrition/Anorexia
6⃣Glycogen Storage Disorders
7⃣Atopic Dermatitis
2/A snow globe is a great analogy to discuss and frame delirium with patient’s families. How well the snow is packed at the bottom of the globe can be thought of as predisposing factors. When the snow globe is shaken it represents active delirium from a precipitating cause.
3/Known predisposing factors for delirium include:
1/ Have you ever heard your friendly pulmonologist use the terms “entrapped” or “trapped” lung and were confused about the terminology? If so you are not alone and this is the tweetorial for you! #MedTwitter#tweetorial@crit_caring_MD@lkbrath@VCU_PCCM@PSinkam
2/Let’s first start with some definitions. The term “non-expandable lung” is an umbrella term that is used to describe when the lung is unable to expand to the chest wall in order to achieve visceral and parietal pleura apposition. @AvrahamCooperMD@michellebr00ks@mdlizs