Why are we singling out factor 8?
It's made in the endothelium, and therefore, will be normal/high in liver disease.
It's a great test, but takes a while to come back.
A neat trick to have in your back pocket?
DIC, like many critical illnesses results in a metabolic acidosis - lactate acidosis, ketosis, and kidney injury - all are potential contributors.
In liver disease, respiratory alkalosis is a common finding, and is attributed to the accumulation of progesterone!