@Docjoshsoc @angie_rasmussen 1) Titer matters. The lower respiratory tract is protected by IgG, the higher your serum IgG, the better. The upper respiratory tract is protected by IgA1, so having mucosal antibodies helps a lot too. High titers matter because they can stop the virus right....
@Docjoshsoc @angie_rasmussen 2) ....when it enters your body. Memory B cells are pretty useful too, but they first need to react and become plasmablasts. For fast acting viruses like influenza this mechanism might contribute to getting less sick, but will likely not prevent you from getting sick.......
@Docjoshsoc @angie_rasmussen 3) ....But since SARS-CoV-2 has a longer incubation period, the plasmablast response (generated from memory B cells) will maybe have a bigger impact. Plasmablasts kick usually in after 5-7 days, which is approximately the mean incubation time of SARS-CoV-2.....
@Docjoshsoc @angie_rasmussen 4) Ideally, you want both: High serum titers/mucosal titers and memory B cells.
