@i_like_stuf @Stanford Well, there's looking at it in absolute values vs relative values (to total LDLp)
It's quite common for hyper-responders to have 30% or less of total LDLp as smLDLp, and indeed both will track with the Inversion Pattern, suggesting metabolic influence...
It's quite common for hyper-responders to have 30% or less of total LDLp as smLDLp, and indeed both will track with the Inversion Pattern, suggesting metabolic influence...
@i_like_stuf @Stanford ... The problem in looking at small LDL particles is that you don't know the composition of the cargo which I believe is very relevant in the reason for its residence and affinity of uptake.
For example, those with severe T2D can have very TG-rich smLDLp...
For example, those with severe T2D can have very TG-rich smLDLp...
@i_like_stuf @Stanford ... Yet LMHRs I'd speculate to have TG-poor, C-rich smLDLp by comparison. This makes physiological since given per-particle depletion of TG depending on demand.
I know some LMHR athletes that have higher % smLDLp following a very intense competition or ultramarathon...
I know some LMHR athletes that have higher % smLDLp following a very intense competition or ultramarathon...
@i_like_stuf @Stanford ... thus, if the periphery is taking more TG in the aggregate from VLDLs, it wouldn't be surprising to see generally smaller sizes overall for downstream LDL particles.
