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Inflammation may be at the root of many chronic diseases. The #LawsonCyclotron has a tracer that can help visualize inflammation at various states of health and disease. 1/
FEPPA is labeled with F-18 like the previous examples this month. It targets the translocation protein, TSPO for short. During inflammation, immune cells like macrophages and microglia become activated and express more TSPO. This generates brighter images 2/
This is not perfect because it cannot differentiate whether it's pro or anti inflammatory. But some great studies out of @CAMHResearch where the probe was developed have provided insight into dementia, psychosis, and mood disorders. 3/
camh.ca/en/science-and…
We are also getting ready to publish exciting clinical results here @lawsonresearch and @SchulichMedDent with Drs. Finger, Anazodo, @DrJeanTheberge and @lena_pl. FEPPA is a popular tracer in #ldnont so stay tuned for cool science to come!
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Justin Hicks
@jay_hickey
An oldie but a goodie: Oxygen-15 water! One of the first isotopes to be used in human imaging, O-15 has a 2 min half-life. That puts a lot of pressure on the #LawsonCyclotron staff to work efficiently 1/
We make it using high energy deuterons. Those are hydrogen atoms with an extra neutrons and a positive charge. These particles hit a N-14 atom, kick out neutron to make O-15. This comes out of the cyclotron as O2 gas 2/
The gas gets mixed with H2 over hot Pt wires where it is reduced to H2O. That bubbles into sterile saline for injection and filtered. We then run it (literally) up 6 floors to the @lawsonresearch hybrid PET/MR @stjosephslondon 3/
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Justin Hicks
@jay_hickey
What makes a nice companion to flortaucipir? Why, florbetapir! As the name suggests, it's job's to target and illuminate beta amyloid. #LawsonCyclotron 1/
Also labeled with F-18, this tracer bind to amyloid plaques in #Alzheimers disease and can assist with diagnosis. It is also approved by the FDA for this purpose. Like it's companion tau tracer, we make it under license and are the sole #Canadian🇨🇦 suppliers 2/
This includes multiple clinical trials for anti-amyloid drugs where the PET scan was used to determine efficacy of the drug. By observing a decrease in PET signal between baseline and post-therapy, the drug could be considered a success 3/
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Justin Hicks
@jay_hickey
Fresh off a recent FDA approval, let's talk about [18F]AV-1451 aka flortaucipir aka Tauvid for #LawsonCyclotron products today fda.gov/news-events/pr…
1/
This probe targets neurofibril tangles which form from clumps of a protein called tau. This occurs during the progression of neurodegenerative diseases such as #Alzheimers. It is a licensed product from Eli Lilly and Avid Radiopharmaceuticals 2/
We add the fluoride made in the cyclotron to a molecule that selectively binds to tau aggregates. The synthesis is automated inside a lead shielded box to protect our amazing technicians from harm. We supply this to site all across southern Ontario.
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