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What makes a nice companion to flortaucipir? Why, florbetapir! As the name suggests, it's job's to target and illuminate beta amyloid. #LawsonCyclotron 1/
Also labeled with F-18, this tracer bind to amyloid plaques in #Alzheimers disease and can assist with diagnosis. It is also approved by the FDA for this purpose. Like it's companion tau tracer, we make it under license and are the sole #Canadian🇨🇦 suppliers 2/
This includes multiple clinical trials for anti-amyloid drugs where the PET scan was used to determine efficacy of the drug. By observing a decrease in PET signal between baseline and post-therapy, the drug could be considered a success 3/
Unfortunately, none of those trials have been huge successes. But we continually get new orders so the efforts to find an AD therapy haven't stopped! 4/
One interesting difference between AV-45 (the old name for this tracer) and AV-1451 is the former has vitamin C added to the injection. The ionizing radiation for the F-18 is sufficient to break some of the chemical bonds on the tracer. 5/
This leads to radicals (single unpaired electrons) forming which lead to cascading reactions to destroy the AV-45. Vit C absorbs these stray radicals and prevents the entire batch from falling apart. Bonus: it's a safe anti-oxidant to inject! 6/
So #VitaminC is for more than just fighting off a cold 🍋🍊. It's also useful for preserving your PET tracer #themoreyouknow🌈⭐
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