When the first white settlers arrived in Montana, the native Salish people warned them to not settle the West side of the Bitterroot River.

Ignoring these warnings, a small group of people colonized that side of the river.

Three quarters-75%-died of a mysterious disease. Image
The Bitterroot river carves out a 75 mile canyon in Western Montana.

It's not deep at all, averaging only about 3 feet. Animals and humans cross it very easily, and it's not really a barrier to any kind of travel.

The Salish believed evil spirits lived in the area.
Saint Mary's mission, founded in 1841, was the first permanent European settlement in Montana.

The European settlers weren't very nice to the natives, and the poor relationship caused the mission to close.
A trading post which mostly serviced trappers, Fort Owen, popped up about 10 years later.

When the owner, John Owen discovered gold in the area, this set off a gold rush in the area.

Unfortunately, the disease on the West side of the bitterroot river made life difficult.
Not much was known about this disease until the early 1800s, when the state board of health brought in Louis Wilson and William Chowning to investigate.

They did a lot of research on the disease, eventually creating the map below Image
At the same time, a few other doctors were sent to investigate along with Williams and Chowning.

Together they found out:

It was caught in springtime
It was caught outdoors
The Salish rarely got the disease
The more these early researchers found out about it, the more mysterious it became.

People became really sore, and developed a fever. A rash of purple spots dotted the body. Some would go blind or deaf. Loss of balance was pretty common.

It didn't appear to be contagious.
The disease remained mysterious, until two doctors L.P. Macalla and H.A. Bereton had a patient who was bitten by a tick.

One which looked a lot like the one below.

That patient later developed the symptoms described in the post above. Image
So they took the tick, and allowed it to bite another healthy person.

They got the disease.

So they fed a tick on that person, and THAT person got the disease as well.

Unfortunately, they didn't publish these results until much later.
At the same time as this was going on, a young microbiologist by the name of Howard Taylor Ricketts set up shop in the area.

With few laboratory supplies-all of his experiments were done in a tent-he began to look for the cause of this perplexing disease. Image
It didn't take too long before he met a local family living in black measles territory. Their son, William, 10 years old, had caught the disease.

When Ricketts came to visit he found...ticks.

Lots of ticks. Everyone in the family had been bitten by them.
So he drew blood from William Langdon, stained it with a chemical called Eosin, and found bacteria.

He dissected ticks in the area, found the bacteria.

He also found that he could pass the disease among guinea pigs.

He also found bacteria in tick eggs.

web.archive.org/web/2011072223… Image
He named this bacteria after himself, Rickettsia rickettsii.

The disease would go on to be well studied, and go by a few other names. However, over time, the scientific community settled on a name originally published in 1903.

Rocky Mountian Spotted Fever Image
The story of this disease is one I've wanted to tell for awhile, and by no means does it end here.

The story of RMSF is a really important cautionary tale for why people like us, those who specialize in outreach, are so important.
In addition, the Bitterroot strain of RMSF has remained a biological mystery that has baffled scientists to this day.

So, next week, I'll be talking about part 2:

The legal war over Rocky Mountian Spotted Fever
Also, on our Deep Dives, we're absolutely terrible at acknowledging our sources and we need to work on this.

Here are the sources we consulted if you want to read more:

ncbi.nlm.nih.gov/pmc/articles/P…

wemjournal.org/article/S1080-…

jstor.org/stable/pdf/414…

jstor.org/stable/4147077…
jstor.org/stable/pdf/301…

Armstrong, M. (2017). Germ Wars: The Politics of Microbes and America's Landscape of Fear (Vol. 2). Univ of California Press.

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More from @BugQuestions

Aug 22, 2021
Why are people poisoning themselves with horse dewormer to treat COVID-19?

Let's explore ivermectin in this week's #DeepDive
Ivermectin is a medication which is perscribed to combat parasites.

It jams itself into chloride channels, permanently turning the nerves off.

It can't do that to people, so it has a pretty good safety profile if you stick to the correct doses.
Okay, but viruses don't have nerves.

So why would an insecticide work on a virus?

It does something else, too. It blocks the import of proteins into the nucleus.

Kind of.

dicyt.uto.edu.bo/observatorio/w…
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May 6, 2021
In 1875, a series of locust swarms the size of California ripped through the Western frontier

Blotting out the sun and causing the modern equivalent of $4 billion in damages, major famines followed in their wake

In 1902, just 25 years later, the species went extinct

#DeepDive
The grasshopper, the Rocky Mountian locust, was once the most numerous animal on the planet.

So numerous, that entomologists didn't bother to collect them.

The only specimens came from a glacier in Montana, which has since melted b/c global warming

formontana.net/grasshopper.ht…
The Rocky Mountain Locust, Melanoplus spreta, once had a range which covered almost the entirety of the US.

It was a highly mobile species which had been collected from Nevada all the way to St. Louis.

It bred mostly in the Rocky Mountain river basin.
Read 20 tweets
May 5, 2021
So, I've been thinking about how to properly respond to this...and there's really no way to do that because we will never be able to take our ecosystems from Earth to other planets.

What Musk proposes here is (as @Myrmecos pointed out) simply impossible.
Let's say, for funsies, that we're able to build some kind of ark.

Well, that ark will only hold the critters humans know about. Maybe the occasional weirdo hanging out on someone else, but heavy bias.
On any practical level, we cannot create an ecosystem.

Yes, ecospheres are a thing. However, it's an ecosystem which supports a handful of species.

No real food webs.
Read 11 tweets
Dec 31, 2018
For our last #DeepDive of 2018, let's talk about a mosquito that you'll be hearing a lot about in 2019.

Aedes aegypti is one of the most important disease vectors in the world.

So...what makes it a good vector, and why is it found worldwide?
Ae. aegypti is a mosquito that's originally from sub-Saharan Africa, adapted to living in the holes in trees.

This genus has a unique egg laying behavior. They lay their eggs on surfaces above water, and those eggs are dormant until the hole fills up.

flic.kr/p/8gXkQf
In it's home range, there are two color forms.

One color form is dark, and doesn't hang out around people.

The second is lighter colored, and pretty much specifically feeds on people.

It's that second one which more or less took over the world.
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Dec 30, 2018
This question, inspired by our cricket packaging thread, is another excellent question.

Even if we're not releasing mosquitoes, why do we need to breed them in captivity?

There's a few reasons...
The most important is a reference strain. Lots of mosquitoes were being bred in labs before pesticides were introduced, so we *know* they're not resistant to them.

If we're curious about a modern population, we can compare and use them as a standard.
Besides reference strains for pesticides, we know that the lab reference strains can transmit most of the 'normal' diseases that Ae. aegypti spread.

However, not all populations of Ae. aegypti spread every disease.

Why is that?

Scientists need to know!

journals.plos.org/plosntds/artic…
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Dec 30, 2018
In relation to that *amazing* cricket unboxing story comes this really awesome question.

How do you get 1,000 SUPER JUMPY crickets into a box in the first place?

Turns out, that's actually a surprisingly easy thing to do.

(Thread)
There is no shortage of videos/guides on how to rear crickets.

It's pretty easy, and you can generally get a few thousand in a rearing box at a time. Essentially, you rear->ship.

...but how do you move them from the rearing box to a shipping box?

It turns out that there are specialized tools for this.

One such tool, that you've probably seen in petstores is a cricket funnel.

This allows you to measure small amounts of crickets by volume, essentially you know roughly how many crickets are needed to reach a certain point.
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