There are significant issues that in my opinion make it basically worthless as an estimate of anything 1/n
This means the authors looked through the literature, and aggregated a bunch of different estimates of the impact of HCQ/CQ on health from different studies
That's not precisely true - meta-analyses are only as good as the included research!
This is INCREDIBLY misleading
Moving on
Some of these numbers are almost certainly wrong
That's very worrying, and hard to explain
This is very concerning
These are obviously related, so aggregating both in the same model is...problematic
In other words, the final, slightly unedited, publishable version
In that context, this methodology is FAR too opaque
That's...worrying
That's less than ideal (newer versions CORRECT mistakes!)
This study is riddled with flaws and almost certainly does not present an accurate estimate of the effect of HCQ or CQ
"Current data do not support the use of hydroxychloroquine for prophylaxis or treatment of COVID-19"
cebm.net/covid-19/hydro…
- inadequately rates risk of bias
- inappropriately combines estimates...
- ...that may have been miscalculated
It is hard to know what to make of this, except to say that the paper itself is not very useful in any way