Biologics are medicines made from living organisms,under monitored conditions, include gene & cell therapies,therapeutic proteins,monoclonal antibodies & vaccines to treat cancer,CKD,other autoimmune diseases
@unseenvalue @punitbansal14
@unseenvalue @punitbansal14
Biosimilars, is a biologic similar to another biological medicine (reference product) already licensed by the US FDA, similar in terms of safety, efficacy, purity
Biosimilar production costs are lower due to lesser number of clinical trials,do not incur costs for marketing, R&D
Biosimilar production costs are lower due to lesser number of clinical trials,do not incur costs for marketing, R&D
Biosimilars,involve 100 to 300 million $ development cost
Time to market 7-8 years
Large molecules upto 2,70,000 Da
Mode - IV,SC
sourced from living organisms
Atleast 1 mandatory clinical trial
15-30% cheaper to biologics
Similar not identical to original drug
@AvinashGoraksha
Time to market 7-8 years
Large molecules upto 2,70,000 Da
Mode - IV,SC
sourced from living organisms
Atleast 1 mandatory clinical trial
15-30% cheaper to biologics
Similar not identical to original drug
@AvinashGoraksha
Generics
Development costs approx 3-4 million $
Time to market 2-3 yrs
Simple small mols upto 300Da
Chemical structure identical to reference drug
Oral dosage
No risk of antibody unlike biosimilars
Made by chemical synthesis
No clinical trials
50-90% cheaper
@AdityaKhemka5
Development costs approx 3-4 million $
Time to market 2-3 yrs
Simple small mols upto 300Da
Chemical structure identical to reference drug
Oral dosage
No risk of antibody unlike biosimilars
Made by chemical synthesis
No clinical trials
50-90% cheaper
@AdityaKhemka5
Advantages of generics
Cheaper by 50 to 90 % compared to branded drugs as R&D costs not involved
Similar in quality, efficacy,purity to parent drug
Lower costs,improve patient compliance patients more likely to adhere to treatment protocol
@Gautam__Baid @varinder_bansal
Cheaper by 50 to 90 % compared to branded drugs as R&D costs not involved
Similar in quality, efficacy,purity to parent drug
Lower costs,improve patient compliance patients more likely to adhere to treatment protocol
@Gautam__Baid @varinder_bansal
Disadvantages of Generic drugs
Not all drugs have generic versions
Takes long for patents to expire
Patients maybe allergic to new flavour,color of generic
Rate of absorption varies betn diff generic versions of same drug
Diff in brand appearance,patient confusion
@kiranshaw
Not all drugs have generic versions
Takes long for patents to expire
Patients maybe allergic to new flavour,color of generic
Rate of absorption varies betn diff generic versions of same drug
Diff in brand appearance,patient confusion
@kiranshaw
Biosimilars market to surge at 27% CAGR till 2025
Applications in hematology,$4552 million revenue in 2018,3 million Americans have anaemia
In Autoimmune diseases,$1387 million revenue 2018,23 million suffer from IBD,RA,Psoriasis
Develpmnt by rDNA technology,80% market 8123mn$
Applications in hematology,$4552 million revenue in 2018,3 million Americans have anaemia
In Autoimmune diseases,$1387 million revenue 2018,23 million suffer from IBD,RA,Psoriasis
Develpmnt by rDNA technology,80% market 8123mn$
Biosimilars market to grow at a faster clip,increased number of patents set to expire,govt cost cutting initiatives,increased prevalence of autoimmune,chronic & cancers where generic medicines may not be possible
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