Thread by @Mangan150

WHY is insulin resistance linked to almost all chronic diseases?

WHY do chronic diseases and the diseases of aging have almost 100% overlap?

Understanding this is critical to seeing why modern medicine focuses on the wrong things (like cholesterol).

As you age, the changes in the body are the same as when the body moves closer to diabetes:

*⬆️ insulin resistance
*⬆️ body fat
*⬇️ muscle mass

Arguably, even the healthiest person will see at least small changes in this direction with age.

Excess food and higher body fat promote these same changes.

One of the drugs proposed to slow aging is metformin, a diabetes drug that lowers glucose and insulin.

That's not a coincidence.

Modern medicine treats chronic diseases separately, when the main cause comes from one source: metabolic dysfunction.

Aging is metabolic dysfunction. Hyperfunction.

There are other things going on in aging, but as @Blagosklonny says, they are not life-limiting

The conclusion: the same things that prevent insulin resistance also prevent chronic disease and slow aging:

*real, whole foods, at least somewhat carb-restricted
*exercise, especially resistance training
*intermittent fasting

all leading to good body composition.

Even if you remained perfectly metabolically healthy, you will of course die some day.

In a sense, discovering the cause of aging and treatments for it means discovering those that lie beyond metabolic health.

But for now, the main task in anti-aging must be metabolic health