This weekend I learned what an intra-cardiac epinephrine is. Wish I could say it was from a π or topic discussion... π Nope, it was John Doe, π w/ cc of traumatic arrest s/p lots and lots of πͺ wounds π... so what is intra-cardiac EPIβββ
Just as it sounds π€¦ββοΈ... EPI π directly into the myocardium. Generally only used in ATLS after performing an ED thoracotomy in conjunction w/ manual cardiac compression
So here are a few clinical pearls I learned from John Doe
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π
[Dosing & Freq] = same as ACLS β‘οΈ 1 mg Q 3-5min.
β There are pre-filled π products specific for intra-cardiac use, but ISMP says βοΈ d/t risk for errors.
Also, there isn't great evidence on what volume to use... what does ur institution use?
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ππ The key differences are in the π length & gauge
β Consider 21- or 22-gauge needle
β Length 1.5" closer to 3.5"... really, whichever you can πββοΈπ¨π¨ faster
πππ Administer via rapid push directly into the L ventricle
β Cardiac massage should be ongoing!
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ππππ Complications include:
Coronary artery laceration, cardiac tamponade, pneumothorax, and can interrupt external chest compression/ventilation
6yo π¦ presents to your ED with multiple deep lacs after being attacked by the neighbor's π... He's screaming/crying in pain but wont let the RN get near him for an IV, looking at the π makes him π even harder.
β Olfactory mucosal absorption leads to rapid therapeutic levels in the CSF.
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A few nerdy PK pearls below:
π Quick onset of action
π Lipophilic drugs = better absorbed
π Unionized drugs π BBB more readily than ionized forms
π IN delivery bypasses GI & first past metabolism, BUT nasal mucosa contains lots of CYP450 enzymes!