This weekend I learned what an intra-cardiac epinephrine is. Wish I could say it was from a πŸ“” or topic discussion... πŸ˜‚ Nope, it was John Doe, 🎁 w/ cc of traumatic arrest s/p lots and lots of πŸ”ͺ wounds πŸ™ƒ... so what is intra-cardiac EPI❔❔❔

1/...

#MedTwitter #TwitteRx
Just as it sounds πŸ€¦β€β™‚οΈ... EPI πŸ’˜ directly into the myocardium. Generally only used in ATLS after performing an ED thoracotomy in conjunction w/ manual cardiac compression

So here are a few clinical pearls I learned from John Doe

2/...
πŸ’Ž
[Dosing & Freq] = same as ACLS ➑️ 1 mg Q 3-5min.
βœ… There are pre-filled πŸ’‰ products specific for intra-cardiac use, but ISMP says ⛔️ d/t risk for errors.

Also, there isn't great evidence on what volume to use... what does ur institution use?

3/...
πŸ’ŽπŸ’Ž The key differences are in the πŸ’‰ length & gauge
βœ… Consider 21- or 22-gauge needle
βœ… Length 1.5" closer to 3.5"... really, whichever you can πŸƒβ€β™‚οΈπŸ’¨πŸ’¨ faster

πŸ’ŽπŸ’ŽπŸ’Ž Administer via rapid push directly into the L ventricle
βœ… Cardiac massage should be ongoing!

4/...
πŸ’ŽπŸ’ŽπŸ’ŽπŸ’Ž Complications include:
Coronary artery laceration, cardiac tamponade, pneumothorax, and can interrupt external chest compression/ventilation

Bottom Line ⏩ Same dose, different needle...& make sure ur πŸ”— to the internet in the trauma bay 😭

PMID: [16759407][10978796]

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More from @TILEDPharmD

24 Sep
6yo πŸ‘¦ presents to your ED with multiple deep lacs after being attacked by the neighbor's πŸ•... He's screaming/crying in pain but wont let the RN get near him for an IV, looking at the πŸ’‰ makes him 😭 even harder.

How do you treat the pain?

(Josh)
1/...
Consider picking πŸ‘ƒ!

How does intranasal drug delivery work?
βœ… Capillary rich respiratory mucosa allows πŸ’Š to directly enter the 🩸(systemic circulation)

βœ… Olfactory mucosal absorption leads to rapid therapeutic levels in the CSF.

Source:[27397490]
2/ Image
A few nerdy PK pearls below:

πŸ’Ž Quick onset of action
πŸ’Ž Lipophilic drugs = better absorbed
πŸ’Ž Unionized drugs πŸ”€ BBB more readily than ionized forms
πŸ’Ž IN delivery bypasses GI & first past metabolism, BUT nasal mucosa contains lots of CYP450 enzymes!

PMID:[30449731]
3/
Read 9 tweets
30 Aug
πŸ‘‹πŸ‘‹ A quick poll to start off this week's TIL
[❔]: Does your institution have droperidol on formulary?

1/
#TwitteRx #MedTwitter #FOAMed #emergencymedicine #NurseTwitter
Droperidol ➑️ butyrophenone, D2 receptor antagonist, similar to haloperidol with
βœ… faster onset (3-10m IV/IM)
βœ… shorter-acting
βœ… more sedating

Dosing = 0.625 - 10 mg
Indications: Agitation, N/V, HA/migraine, vertigo, adjunct analgesic

ADEs = EPS, hypoTN, QTp
Preg = C

2/
[1961]: Developed
[1960s - 2000]: Frequently used in ED

[2001]: FDA ⬛️ Warning d/t QT prolongation & TdP + coincides w/ drug shortage of πŸ’‰ products ⏩ ultimately withdrawn from market πŸͺ¦

[2019]: American Regentℒ️ announces droperidol is back πŸ‘€... so is it worth the risk?

3/
Read 9 tweets

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