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Martin Borch Jensen Profile picture
@MartinBJensen
Sep 6, 2020 • 4 tweets • 3 min read • Read on X
I've been hunting for a delicious decaf coffee, and @elamadej gifted me this @Timelesscoffee (thanks!). At first it looks just high-end artisanal, but then things get a bit strange... Image
An apostle, sure. #CoffeeIsMyReligion and such things. A bit unusual but nice graphic design. Image
Well, this is a bit beyond the usual. Why seven fingers? The eye presumably the esoteric mysteries I'll learn after drinking this? But still, this is #BayArea and I've certainly seen cultier startups than this. Image
But then we get to the back...
Is this a straight up Guyana call-to-group-suicide? Level 10 culting for sure.
Or is it a call to leave the Bay? Did they start COVID? What is this core of which they speak?
Such knowledge is not for the uninitiated, I suppose. But good coffee ☕ Image

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More from @MartinBJensen

Martin Borch Jensen Profile picture
Mar 4
Finding new medicines is getting more and more expensive, and AI won't help much unless we can generate physiological data at scale.

In our new preprint, @GordianBio extends the progress of the functional genomics community to run pooled in vivo screens at scale, in a way that answers questions about physiology and therapeutic potential.
We show screens in mice and horses, fibrotic and degenerative disease, with a framework for physiological predictions validated in human ex vivo tissues.

Very proud of @v_sontake, @vkartha88, Neety and the rest of the team. Tweetorial follows:Image
Perturbation is how we extract rules from the organized chaos of biology, and high-throughput pooled screens have become a major source of new insights.

But when we screen cells outside the body, we're missing a lot of what drives disease: no immune system, no real metabolism, no structural environment.

Diseases of aging happen at the organ level. So we need screens that can ask cells about the organ they're in. This means screening in vivo.Image
We had to solve three challenges for pooled screening in diseased organs: delivering different perturbation modalities even in organs with structural damage, scaling this to large perturbation libraries, and a way to analyze scSeq data that ranks targets' therapeutic potential.

The result is what we call Mosaic Screening, because you end up with a mosaic of different perturbations inside a living, diseased organ.Image
Read 10 tweets
Martin Borch Jensen Profile picture
Mar 31, 2024
I'm struggling to wrap my head around the new Weissman lab myHSC depletion paper:
The first authors don't seem to be on twitter but hoping I can crowdsource a fun discussion. @dbgoodman @ImmunoFever @Jeff_Mold @Satpathology @CalebLareau...nature.com/articles/s4158…
The premise of the paper is that immune function declines with age in part because a haematopoetic stem cell (HSC) population skewed towards myeloid lineage increases in prevalence, and that targeting this population with antibodies can restore function. Cool idea!
❓1⃣: How well defined are myHSCs?
Here myHSC seems to be defined as CD150 high, based mainly on Beerman 2010 .
But looking at Figure 3, CD150 expression is a continuous distribution. Is this a clear cell population with somewhat understood behavior? pnas.org/doi/full/10.10…
Image
Read 11 tweets
Martin Borch Jensen Profile picture
Jul 5, 2022
If you want to build a career in biotech, should you get a PhD after college or join a company directly (as a Research Associate/RA, usually)?
There's no single answer, but I have the conversation often enough that I thought I'd share some pros/cons... (1/n)
First, see this thread about different types of biopharma companies. For reasons I'll get into, I think early stage (probably founder led) biotech is your best bet unless you still want to do PhD later.
(PS if you want to be a professor, it's 💯 PhD) 2/n
PhD will give you more options.
Some companies (incl. @GordianBio) will help you grow from RA to Scientist role (and beyond). But many, esp larger, companies have a glass ceiling if you don't have a PhD. Even if you pick one w/o glass ceiling, you'll be worse off it if fails. 3/n
Read 13 tweets
Martin Borch Jensen Profile picture
Jul 3, 2022
All these points resonate, for early stage biotech at least. @erlichya touches on this, but I think worth separating "industry" into different clusters that will feel quite different to someone coming from academia (still oversimplified, of course):
Pharma (eg Pfizer) vs biotech:
You wear fewer hats, see less of the company but company as a whole spans wider range of expertise, fewer changes in direction, often higher income but no chance of getting rich. Both have job insecurity: pharma doesn't go die but programs do.
Clinical vs R&D stage biotech:
Clinical may still have R&D but it's no longer the biggest driver of success vs failure. Assay validation/rigor > assay development/invention. Clinical can feel more like pharma, but with more urgency/stakes: one program = life or death of co.
Read 7 tweets
Martin Borch Jensen Profile picture
Jan 24, 2022
#SciTwitter After a lot of research and asking around, I'm making the lab equipment recommendations 🧵 I wish I'd had 2 months ago. RT/share with a #newPI or startup 🔬⚗️🛒
Note, much of the equipment hasn't arrived yet, will add comments after actual use.
-80 #freezer
Two clear winners: PHC (@panasonic) and Stirling Ultracold. Both low energy, quiet, reliable. We went with PHC because I know those to last many years, and slightly cheaper.
Thanks @MarcoJost_ @letUbeU @aryelipman #MBCBiolabs
-20 #freezer
Less clear, many viable options. We ended up getting a split of PHC MDF -30 (recommended as quieter) and much cheaper Corepoint Scientific/@VWR, will see which we prefer. Thermo hasn't failed #MBCbiolabs, but $$$ and several people said poor customer support.
Read 14 tweets
Martin Borch Jensen Profile picture
Jan 5, 2022
Something is changing about how scientific research is funded.

@Jasonmmast @endpts covers a growing set of science funding experiments: endpts.com/inside-the-mul…
These include high-throughput grants (e.g. #Fast, #Impetus), new institutes (@ArcadiaScience, @AltosLabs, @arcinstitute... I guess A is for new beginnings?), and new structures like 'nonprofit startups' (@Convergent_FROs) & @newscienceorg.
As with all experiments, I expect that some of these will disappear and that others will be a central part of science in ten years.
But them happening at all is enough to renew a conversation about how science is funded and conducted.
Read 9 tweets

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