Aging, Systems Biology, Gene Therapy. CSO @GordianBio, doing pooled therapeutic screens in vivo.
Also @impetusgrants, https://t.co/KWEUni9245. Prev K99 Fellow @BuckInstitute
Jul 5, 2022 • 13 tweets • 5 min read
If you want to build a career in biotech, should you get a PhD after college or join a company directly (as a Research Associate/RA, usually)?
There's no single answer, but I have the conversation often enough that I thought I'd share some pros/cons... (1/n)
First, see this thread about different types of biopharma companies. For reasons I'll get into, I think early stage (probably founder led) biotech is your best bet unless you still want to do PhD later.
(PS if you want to be a professor, it's 💯 PhD) 2/n
All these points resonate, for early stage biotech at least. @erlichya touches on this, but I think worth separating "industry" into different clusters that will feel quite different to someone coming from academia (still oversimplified, of course):
Pharma (eg Pfizer) vs biotech:
You wear fewer hats, see less of the company but company as a whole spans wider range of expertise, fewer changes in direction, often higher income but no chance of getting rich. Both have job insecurity: pharma doesn't go die but programs do.
Jan 24, 2022 • 14 tweets • 8 min read
#SciTwitter After a lot of research and asking around, I'm making the lab equipment recommendations 🧵 I wish I'd had 2 months ago. RT/share with a #newPI or startup 🔬⚗️🛒
Note, much of the equipment hasn't arrived yet, will add comments after actual use.
Thrilled to announce the Longevity #Impetus Grants, $21M+ towards basic research that could accelerate our understanding and control of human aging.
We welcome proposals from researchers in- and outside the #Aging field. Please share!
More info: impetusgrants.com & this 🧵
Impetus Grants are $10k-500k (w max 10% overhead). Smaller requests favored, to support more projects. No project period and no strings attached. Scientists at non-profits worldwide can apply with ideas that shift perspectives & capabilities in #Aging research, starting Sep 13th.
Jun 23, 2021 • 7 tweets • 4 min read
Arlan Richardson showing that JAX-housed mice, like humans, have undergone a dramatic improvement in #lifespan this century ... by reducing deaths from pathogens. #MindYourModels
Recommends looking at lifespan data as the best indicator of husbandry quality at different institutions/sources. Mean survival should be at least 27-30 months.
Dec 20, 2020 • 13 tweets • 8 min read
I'm often asked how to learn about #AgingBiology, which I hope this thread can address.
Will first list recommended introductory resources, then contextualize and interpret.
There's exciting progress! But also many fanciful ideas, so you can't take everything at face value.
Will mostly skip the Why/philosophy of #AntiAging, since those asking for resources are likely already bought in.
Very excited (enough to get up at 5am) about this Temporal Single Cell Analysis organized by @singlecellomics. First talk by the amazing Caroline Uhlers, recently snagged from MIT by @ETH_en#SCOGtempSC#SingleCell
Livetweets here. Apologies in advance to any sophisticated 'ML on scSeq/spatial' presenters whose work I misinterpret/misrepresent, still a novice to that field.
Sep 6, 2020 • 4 tweets • 3 min read
I've been hunting for a delicious decaf coffee, and @elamadej gifted me this @Timelesscoffee (thanks!). At first it looks just high-end artisanal, but then things get a bit strange...
An apostle, sure. #CoffeeIsMyReligion and such things. A bit unusual but nice graphic design.
Sep 1, 2020 • 24 tweets • 11 min read
Livetweets from the 7th Annual Aging Research and Drug Discovery conference #ARDD2020. I can't attend every talk to coverage will be intermittent. Apologies to any speakers left out!
Christian Riedel from @karolinskainst presenting aging clocks. There are a lot of these, but excited to see him (A) making a human clock predicting time to death, not just age, and (B) deconvoluting both their human and model org clocks into FUNCTIONAL parameters. Sorely needed.
OK, looks like Democracy is safe for now, and the push for reform is making headway. There's a long road ahead, but I'll take a brief timeout to report from @NYASciences's #Phenotypic2020 virtual conference.
First keynote was @OlgaTroyanskaya, presenting a range of tools for understanding #NonCoding genomic variants: DeepSEA, ExPecto, Fenrir...
Emphasizes that #ComplexDisease relies on networks and complex changes like #Aging, so we have to stop looking for 1->1 causal maps. Agree!
May 13, 2020 • 8 tweets • 3 min read
Two #ASGCT20 morning sessions focused on lung delivery. Cool work, but it seems to me that the big issues for clinical stage haven't really been addressed:
#AAV can target specific cell types in the lung, and multiple groups have rescued mouse models of genetic diseases. But both new and old lung-trophic capsids seem to hit T2 epithelial cells, which turn over and lose non-integrating transgenes.
Sharing takeaways and recs from recent reading blocks.
Who would I recommend this to?
🏆 Any interest in topic
🎖️ You often read on this topic
Michelin, not Amazon, style ratings = any non-🍅 is a good book.
Keynes Hayek by @NWapshott
Layperson's history of JM Keynes' inventing #macroeconomics, and opposition by ppl who fear inflation > unemployment.
• #Stimulus packages are <100y old
• They seem like magic, but aren't
• Fiscal policy goes beyond red vs blue
Mar 18, 2020 • 4 tweets • 3 min read
In my experience, one of the more effective ways to feel better when facing #anxiety or #depression is to act selflessly. Helping others makes me feel valuable and capable. Even, and especially, when it seems I should worry about other things.
Our cortisol-fueled response is to close ranks, protect our turf and mistrust strangers. That's the easy thing to do, but it only fuels the response and make us more worried. So try doing something to help someone else, just for the sake of it.
Mar 5, 2020 • 5 tweets • 5 min read
Dear #GeneTherapy twitter, thank you for your had work enabling cures for diseases of #Aging. What's that, you aren't working on that at all? Oh but you are, and @Nicole_Paulk and I wrote an oped to explain why: cellandgene.com/doc/why-comple…#Aging is a set of biological mechanisms that cause all your tissues to decline in distinct ways, and in doing so lose physiological coherence. This process is the main risk factor for most US deaths (incl. #COVID19).
Jan 11, 2020 • 5 tweets • 7 min read
This is a very nice piece: bit.ly/2TcSZz1. @johnsalvatier points out a fundamental feature of #invention, whether in research or creating technology (thread)
You have a problem and can see/measure misc. details of it. Some of these are key to solving the problem, and they are right before your eyes. But they are INTRINSICALLY not distinguishable from the rest until you know how to solve the problem=which ones are important.
In the midst of #AcademicPatentGate, @Nicole_Paulk and I started talking more broadly about the ideal relationship between #Academia and for-profit in the field of #biotechnology. Should ties be stronger or weaker? What happens when #OpenAccess meets the global economy?
One side: For-profit companies license academic innovations that used public research #funding, then charge the public for the products.
Other side: Public research funding has the goal of fueling innovation. Restricting discoveries to the academic community is not beneficial.