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Giving talks in which you don't have a slide deck already made is illuminating. Look what I found out about publication bias>
It was "discovered" in 1979 by Rosenthal content.apa.org/record/1979-27…
How did he do this?
Thread ...
He used a variant of ...sit down for this...the Fragility Index, which we reported on in cardiology
ahajournals.org/doi/10.1161/CI…
The criticism was fierce. But I liked it. @ShahzebKhanMD
Here's Rosenthal's explanation

I am no stats person but this looks a lot like a fragility concept applied to all studies.
Rosenthal's conclusion -- prescient.
Here is Steve Nissen in 2013 in @JAMAInternalMed jamanetwork.com/journals/jamai…
Clinical trial registration has probably got us to a better place now. But still, I think this supports a #medicalconservative approach to evidence translation.
Happy to hear thoughts on this from anyone. cc @kaulcsmc @gcfmd @AndrewFoy82 @califf001
@LuisCLCorreia
I know @eturnermd1 has a wonderful paper in NEJM on this issue with anti-depressant drugs
(I wonder if most patients know about this? These drugs are super common) nejm.org/doi/full/10.10…
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