The last few weeks it has been clear the U.K. is sliding into a pandemic resurgence, and is very poorly placed to deal with it 1/n theguardian.com/politics/2020/…
Why? Because testing has collapsed. The plans, focusing on symptomatic contacts, were flawed IMO, but even these cannot now get a test 2/n
Meanwhile schools are back, with minimal fig leaves of infection prevention. Without testing asymptomatics we will never know how many outbreaks there are there, but schools *will* add to transmission cdc.gov/mmwr/volumes/6… 3/n
(This is not a reason to close schools forever, it is a reason to keep transmission low enough to allow schools to remain open, like they are in NZ, SK, Denmark etc Bluntly education is more important than Pret) 4/n
Now some more epi observations. A doubling time of ~7 days suggests an Rt somewhat more than is currently reported. But it’s hard to be definitive. Why? The messed up testing 5/n
As testing collapses it takes with it the state of ‘situational awareness’ which is so vital to handling any emergency. In infectious disease it is essential to understanding how risks are changing with time 6/n
The U.K. has talked up a ‘whack-a-mole’ approach to targeted shutdowns. This is not necessarily a bad idea, but it falls apart without testing. You can’t whack a mole if you don’t know where it is, duh 7/n
I should be clear that testing improved so much over the summer that a vastly larger fraction of the less severe cases have been identified, mostly in younger people. Action in the spring took place at a much later stage of the epidemic curve 8/n
But that’s why the lack of testing matters so much. If you see the virus coming you can take action early. If you wait for those lagging indicators of hospitalizations and deaths you’re already too late. We should know that from too much bitter experience 9/n
While I am glad the @GOVUK or at least some people within it seem to be taking it seriously, they will struggle to overcome months of confused infantilising messaging about ‘world beating’ testing and ‘moonshots’. The virus doesn’t pay attention to news briefings 10/n
Instead of over promising and under delivering, focus on being adequate to the task. Stop pretending things will be ‘over by Christmas’ and be straight with people. There are testing times ahead in both senses of the word 11/end

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More from @BillHanage

10 Sep
This is the tweet I pinned back in March. I want to say a few things about panic and preparedness 1/n
In an emergency, it is reasonable and responsible to minimize panic. However this is not done by denying the existence of the emergency - at best that delays the panic and at worst it magnifies the panic once the truth becomes clear 2/n
Instead earn trust. Honestly present the reality of the situation and reassure people that you are working to control it and minimize the fallout. Work with expert risk communicators 3/n
Read 6 tweets
24 Aug
Some things worth noting about this. 1) it really does look like a reinfection if the sequence is that different and typical of what is circulating in Spain 1/n nytimes.com/2020/08/24/hea…
2) so this shows that reinfection is possible, it doesn't tell us how common it is. That will be a function of how much immune protection exists, and exposure to the virus (depends on current prevalence) 2/n
3) Hong Kong keeps a close eye out for things like this, so it's maybe not surprising it was reported from there. Should remember that when thinking about how common reinfection is 3/n
Read 6 tweets
14 Aug
This is a phenomenal article on the potential of different sorts of testing, and the ways that we are limited by demands for sensitivity and specificity. There's one important thing it misses out, which I will come to later in this thread 1/n theatlantic.com/health/archive…
Different sorts of questions need different sorts of tests. The US has got hung up on tests and testing, to the extent that it can seem some people think that testing is on its own a sufficient pandemic response. It’s not. It’s just keeping score 2/n
The crucial thing is not the test itself it is what you do in response. For instance to ensure appropriate treatment of cases in a healthcare setting, you want a very sensitive and specific test – meaning you can trust the result because getting it wrong matters 3/n
Read 17 tweets
9 Aug
This is part of a long and excellent thread that is worth reading in its own right. I am almost entirely in agreement. With the exception that I want to write more about the risk of airborne transmission in superspreading 1/n
Superspreading likely follows a "Series of Unfortunate Events" (great show) however we also think that the transmission of this virus is driven by superspreading events, so they must be common enough to make up for the many that do not transmit 2/n wellcomeopenresearch.org/articles/5-67
And those superspreading events are hard to explain without some recourse to airborne/aerosols. Look at this from @kakape quoting @ChristoPhraser sciencemag.org/news/2020/05/w… 3/n
Read 15 tweets
3 Aug
Some thoughts on early to mid pandemic dynamics in the US and the UK

Yesterday I criticized the criticism in this (meta!). But it is worth pointing out that this is after the UK gleefully (irresponsibly?) opened pubs on the 4th of July weekend.

theguardian.com/world/2020/aug… 1/n
The UK and the US offer similar models of pandemic response. Both are bad.

In both, leaders have sought to minimize the consequence of the pandemic, suggesting it will go away ‘magically’ or that normality will be resumed ‘by Christmas’. Both have been mugged by the virus 2/n
Let us start with the US which I know best. We have had months of case counts rising which were predictably followed by deaths. And I do mean predictably look at this (quoting me, predicting it )

msnbc.com/rachel-maddow-… 3/n
Read 14 tweets
30 Jul
OK some thoughts on the fraught situation with schools and the pandemic. There’s been quite a few good opeds on this recently. I hope to add something useful below 1/goodnessknows
Point 1: all kids are not alike. Older ones transmit like adults. It’s hard to say that high schools *drove* the surge in Israel following wide reopening but it is easy to say they didn’t help haaretz.com/israel-news/.p… 2/n
Point 2: household studies of transmission in kids are biased. Because if you detect your index cases by looking for symptoms, you’re not going to catch the kids who are less likely to have symptoms as index cases. Duh. Did I mention non-symptomatic transmission is a thing? 3/n
Read 18 tweets

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