Thread 2/10: Some large particles settle out of the air quickly because of gravity (2 m [6 ft] distancing rule), but majority are smaller particles that stay aloft travel beyond 2 m (6 ft)...large outdoor events often preceded or followed by indoor crowds at bars pubs restaurants
Thread 3/10: ...failure to control the pandemic is a style of political leadership that has been termed medical populism, political leaders “simplifying the pandemic by downplaying its impacts or touting easy solutions or treatments, spectacularizing their responses to crisis..."
Thread 4/10: ...three case studies: US President Donald Trump, Philippine President Rodrigo Duterte, and Brazilian President Jair Bolsonaro...medical populism stokes opposition to simple measures such as wearing face masks, and it breeds misinformation and rumour trafficking.
Thread 5/10: In the United States, COVID-19 is causing historic decimation of Hispanic communities across the south, African American communities in the southeast, and Native American communities in the southwest.
Thread 6/10: The United States is not alone on this front. Across the G20 nations, there are rising cases of COVID-19 among people who are poor and living amidst wealth, a situation that has been called “blue marble health” muse.jhu.edu/book/75688
Thread 7/10: We are concerned about the emphasis and focus on new and unproven vaccine technologies, which will be expensive and have not been shown to offer benefits (in terms of vaccine immunity or safety) over traditional and far less expensive...approaches
Thread 8/10: ..the latter could be produced by members of the Developing Country Vaccine Manufacturers Network dcvmn.org and are more likely to provide vaccines to low-income populations and nations.
Thread 9/10: Along these lines, there is a need for better acceptance of low-cost adjuvants with long-standing safety records, such as alum, which have so far been dismissed by major donors and international partners without scientific rationale
Thread 10/10: ...vaccine nationalism, in which individual nations tie up the intended supplies of future vaccines, is counterproductive...Bilateral negotiations on future vaccine access are currently taking place under confidentiality agreements, with poor transparency in pricing
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Many thanks @BBCWorld for hosting me today to discuss new FDA guidelines for annual COVID immunizations and boosters, including a shift away from universal immunization recommendations to those >65 or a list of underlying health conditions as detailed in @NEJM
My concern is that the new recs are based only on acute sequelae including case fatality rates and hospitalizations, but ignore the chronic consequences such as long COVID or thromboembolic complications that can occur even in well adults and teens
While the companies can do new clinical trials for health adults or kids I’m guessing this might not be of interest due to the size of the trials required and the ginormous costs
My latest in PLOS Biology: it’s not as dark as you might think, there are still lots of opportunities, but they require strategy, long-term planning, openness to the realities that things will be different. Here are some ideas
1/n Being about the role of Vitamin A and its role in the treatment and prevention of measles. It’s actually an interesting story, but unfortunately one that is being twisted and weaponized by the wellness/influencer $multibillion to push vitamin A like they did for ivermectin
2/n it starts from an interesting findings 1970s/80s that kids in low-income countries with malnutrition and vitamin A deficiency (and xeropthalmia) had higher mortality from infection. Al Sommer an ophthalmologist from @JohnsHopkinsSPH led those studies
@JohnsHopkinsSPH 3/n Dr. Sommer who went on to become dean at @JohnsHopkinsSPH also demonstrated in Tanzania a therapeutic benefit for hospitalized kids under 2 with measles. I think those studies are sound, but remember they’re malnourished kids or with xerophthalmia
Disastrous measles epidemic in my state of Texas now up to 48 in 4 counties: my chart on what happens when children acquire measles vs a very safe and effective MMR vaccine. From my new paper in @PLOSGPH
Long COVID impacting more than 1 million children: CDC study suggests. Also a reason why it was important to vaccinate kids vs COVID. It wasn’t only about deaths and hospitalizations. Covid vaccines reduce the risk of long Covid. Papers attached abcnews.go.com/Health/long-co…