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Mikhail V. Blagosklonny, MD, PhD Profile picture
@Blagosklonny
Sep 24, 2020 • 5 tweets • 2 min read • Read on X
Out of my 91 papers on rapamycin, I select five for a brief introduction and historic perspective

1.Most recent and comprehensive analysis why rapamycin can and should be used to treat aging and prevent diseases

ncbi.nlm.nih.gov/pmc/articles/P…
2. By 2010, 12 predictions of mTOR theory of aging have been confirmed (including life extension in mice). “The only prediction remained in 2010 to be confirmed: rapamycin will become the cornerstone of anti-aging therapy in our life time”

pubmed.ncbi.nlm.nih.gov/20436272/
3.In 2010, Intermittent (6 days per 4 weeks) administration of Rapamycin slows aging and extends maximal lifespan in mice

ajp.amjpathol.org/article/S0002-…
4. In 2008. mTOR drives cellular senescence and rapamycin suppresses senescence

pubmed.ncbi.nlm.nih.gov/19471117/
5.Original hyperfunction theory of mTOR-driven programmed-like aging and rapamycin applications to treat all age-related diseases by suppressing aging

pubmed.ncbi.nlm.nih.gov/17012837/

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More from @Blagosklonny

Mikhail V. Blagosklonny, MD, PhD Profile picture
Oct 6, 2022
1/
 Should we decrease protein uptake to live longer? Does growth hormone (GH) therapy promotes healthy lifespan in the elderly or it makes the elderly age faster? Here are some answers (not medical advice).
2/
 It was shown that protein-restriction (and especially certain amino-acid restriction) as well as GH deficiency extends lifespan, whereas high protein uptake and GH decrease lifespan. BUT (big but)...
3/
 This only increases lifespan when protein restriction and GH deficiency happens very early during developmental growth. For example, GH deficiency should be implemented during first 6 weeks after birth in mice
Read 9 tweets
Mikhail V. Blagosklonny, MD, PhD Profile picture
Sep 24, 2021
1/5
In 2014, I published "Koschei the immortal and anti-aging drugs" presenting anti-aging combo/recipe. Dr Alan Green named it Koschei formula and implemented in the clinic (by now he develops his own formula)
pubmed.ncbi.nlm.nih.gov/25476900/#&gid…
2/5
Since that time, I have significantly updated the formula. One of notable change is Low Carb instead of Low Fat diet. Importantly, now there are many Koschei formulas depending on a particular person. It is addressed to MDs not patients.
3/5
 Before I publish them, I present here One personalized example, suited to me
In order of importance
on the next page:
Read 5 tweets
Mikhail V. Blagosklonny, MD, PhD Profile picture
Sep 1, 2020
1/3Some senolytics (drugs that kill senescent cells selectively) may work because they are not senolytics, instead inhibiting kinases, including mTOR, acting as gero-suppressants
2/3Pure senolytics, a form of chemotherapy, are not selective enough for senescent cells, killing non-senescent cells too. Second, in some cases, killing senescent cells can further impair organ function. Imagine killing senescent neurons, beta-cells, retinal cells.
3/3There are solutions to these problems but clinical applications should be chosen very well to make senolytics work as intended.
Otherwise clinical trials of senolytics will fail one after another
Read 4 tweets
Mikhail V. Blagosklonny, MD, PhD Profile picture
Jun 25, 2020
@nntaleb
1/3 Every day we play Russian Roulette. Our decisions are NOT based on the probability of death. Instead, we do what other people do and especially ! what we already done successfully.
2/3 COVID-19 death probability for young girls >> old men (perhaps 1000 fold). But I observed that more old men than young girls are not wearing masks in the park.
3/3 The probability of death from: smoking > car accidents > > shark attack. People avoided swimming last year at Cape Cod watching others; no one avoids driving; smoking depends on other people smoking. And NOT taking rapamycin in theory maybe even more dangerous than smoking
Read 4 tweets
Mikhail V. Blagosklonny, MD, PhD Profile picture
Jun 5, 2020
“Fast food” is food that is prepared quickly and is eaten quickly or taken out.
I do not see anything bad in fast food, except that it contains a lot of carbs. Without carbs (bread, fries etc) it would be called ketogenic diet (almost)
The focus should be shifted from whether food is "fast" or "slow" to carb content. Zero carb fast food seems fine to me. Fast meat without bread for example
I see more problems with "Panera" type of food that is considered "slow" food but intentionally (!) based of High-Carbs recommendations (and low fat).
Read 8 tweets
Mikhail V. Blagosklonny, MD, PhD Profile picture
Mar 10, 2020
1/3 #Aging is the main problem during #coronavirus epidemic. Coronavirus is not lethal before aging (< 18 yo) and mortality increases exponentially with age, like mortality from aging itself. We may say that people still die from aging which allows the virus to become lethal
2/3 If infected, a person has ~ 3 times more chances to die compared with usual age-related mortality during one year For example (numbers are approximate), a 60 yo woman already has 1% chances to die before 61 birthday and ~3 % from the virus.
3/3 At age 80, ~ 5% natural death before 81 birthday and ~ 15% if infected.
Would anti-aging medicine of the future be helpful to decrease overall lethality?
Read 4 tweets

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